天花疫苗接种活动导致了与年龄相关的人群对猴痘病毒的交叉免疫。

IF 3.6 4区医学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of General Virology Pub Date : 2024-06-01 DOI:10.1099/jgv.0.001999

Kieran Dee, Maria Manali, Laura A Bissett, Jordan Bone, Callum Magill, Chris Davis, Brian J Willett, Pablo R Murcia

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引用次数: 0

摘要

猴痘病毒（MPXV）在人与人之间传播的增加令人担忧，而针对疫苗病毒（VACV）的抗体可对猴痘病毒产生交叉保护作用。我们使用来自苏格兰患者群体的 430 份血清样本来研究抗体介导的针对 MPXV 的交叉中和作用。通过将电化学发光免疫测定与活病毒中和测定相结合，我们发现在英国常规提供天花疫苗接种时出生的人体内可交叉中和 MPXV 的抗体水平有所提高。我们的研究结果表明，年龄是天花病毒感染的一个风险因素，1971 年后出生的人接触天花病毒后感染的风险更高。

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Smallpox vaccination campaigns resulted in age-associated population cross-immunity against monkeypox virus.

Increased human-to-human transmission of monkeypox virus (MPXV) is cause for concern, and antibodies directed against vaccinia virus (VACV) are known to confer cross-protection against Mpox. We used 430 serum samples derived from the Scottish patient population to investigate antibody-mediated cross-neutralization against MPXV. By combining electrochemiluminescence immunoassays with live-virus neutralization assays, we show that people born when smallpox vaccination was routinely offered in the United Kingdom have increased levels of antibodies that cross-neutralize MPXV. Our results suggest that age is a risk factor of Mpox infection, and people born after 1971 are at higher risk of infection upon exposure.

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来源期刊

Journal of General Virology 医学-病毒学

CiteScore

7.70

自引率

2.60%

发文量

审稿时长

3 months

期刊介绍： JOURNAL OF GENERAL VIROLOGY (JGV), a journal of the Society for General Microbiology (SGM), publishes high-calibre research papers with high production standards, giving the journal a worldwide reputation for excellence and attracting an eminent audience.