一种新型强效红细胞生成刺激剂 pegmolesatide 的建模和生物学评估。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-06-11 DOI:10.1080/10286020.2024.2362376

En-Jia Zhou, Xu-Li Lang, Min-Jian Yang, Han-Yu Sun, Meng-Yao Hao, Jing Jin, Bao-Lian Wang, Ai-Jun Li, Xiao-Jian Wang

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引用次数: 0

摘要

聚乙二醇化肽基合成红细胞生成刺激剂（ESA）--聚乙二醇化肽（Pegmolesatide）最近在中国获得批准。Pegmolesatide是从哺乳动物体内的天然产物--内源性促红细胞生成素（EPO）的结构中提取出来的。本研究通过计算机辅助分析和生物试验，比较了培高乐塞与重组 EPO 和氨甲酰化 EPO（CEPO）的体外效应和选择性。研究结果表明，与 EPO 和 CEPO 相比，pegmolesatide 对红细胞生成的刺激作用与 EPO 相同，但副作用较小。

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Modeling and biological evaluation of pegmolesatide, a novel and potent erythropoiesis-stimulating agent.

Pegmolesatide, a synthetic, polyethylene-glycolylated, peptide-based erythropoiesis-stimulating agent (ESA), has been recently approved in China. Pegmolesatide is derived from the structure of endogenous erythropoietin (EPO), a natural product in mammals. This study compared the in vitro effects and selectivity of pegmolesatide to those of recombinant EPO and carbamylated EPO (CEPO) through computer-aided analyses and biological tests. The findings indicate that pegmolesatide exhibited the same stimulating effect on erythropoiesis as EPO with fewer side effects than EPO and CEPO.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.