45Ti]Ti-DOTA 复合物的合成与稳定性：迈向基于 45Ti 的杂大环放射性药物之路。

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2024-07-09 DOI:10.1039/d4cc01800a

引用次数: 0

摘要

我们报告了将 DOTA 用作钛螯合剂的情况。我们对所得到的复合物进行了全面的表征，体外稳定性研究表明，它对反金属化和反螯合具有很高的动力学惰性。通过一种基于愈创木酚的液-液萃取方法，用 45Ti 对 DOTA 进行放射性标记，可获得高达 98% 的放射化学转化率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis and stability of the [45Ti]Ti–DOTA complex: en route towards aza-macrocyclic 45Ti-based radiopharmaceuticals†‡

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Synthesis and stability of the [45Ti]Ti–DOTA complex: en route towards aza-macrocyclic 45Ti-based radiopharmaceuticals†‡

We report the use of DOTA as a chelator for titanium. The resulting complex is fully characterised and in vitro stability studies reveal its high kinetic inertness against transmetallation and transchelation. The radiolabeling of DOTA with ⁴⁵Ti, via a guaiacol-based liquid–liquid extraction method, leads to a high radiochemical conversion up to 98%.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.