了解高血糖中的金黄色葡萄球菌：毒力因子和代谢适应性综述。

IF 3.8 3区医学 Q2 CELL BIOLOGY

Wound Repair and Regeneration Pub Date : 2024-09-01 Epub Date: 2024-06-09 DOI:10.1111/wrr.13192

Madeline J O'Connor, Angelica V Bartler, Kelly C Ho, Kenneth Zhang, Rolando J Casas Fuentes, Bradley A Melnick, Kristin N Huffman, Seok Jong Hong, Robert D Galiano

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引用次数: 0

摘要

金黄色葡萄球菌是糖尿病皮肤和软组织感染中最常检测到的细菌之一。糖尿病患者皮肤和软组织感染的发生率和严重程度都较高，这表明高血糖和感染之间存在着一种增效机制。本综述旨在探讨金黄色葡萄球菌在高血糖条件下的代谢和毒力因子适应性。本文纳入并总结了已确定研究的原始数据。了解高血糖、新陈代谢和毒力因子之间的关系有助于深入了解金黄色葡萄球菌引起的糖尿病皮肤和软组织感染的复杂性。

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Understanding Staphylococcus aureus in hyperglycaemia: A review of virulence factor and metabolic adaptations.

Staphylococcus aureus is one of the most commonly detected bacteria in diabetic skin and soft tissue infections. The incidence and severity of skin and soft tissue infections are higher in patients with diabetes, indicating a potentiating mechanism of hyperglycaemia and infection. The goal of this review is to explore the metabolic and virulence factor adaptations of S. aureus under hyperglycaemic conditions. Primary data from identified studies were included and summarised in this paper. Understanding the nexus of hyperglycaemia, metabolism, and virulence factors provides insights into the complexity of diabetic skin and soft tissue infections attributed to S. aureus.

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来源期刊

Wound Repair and Regeneration 医学-皮肤病学

CiteScore

5.90

自引率

3.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Wound Repair and Regeneration provides extensive international coverage of cellular and molecular biology, connective tissue, and biological mediator studies in the field of tissue repair and regeneration and serves a diverse audience of surgeons, plastic surgeons, dermatologists, biochemists, cell biologists, and others. Wound Repair and Regeneration is the official journal of The Wound Healing Society, The European Tissue Repair Society, The Japanese Society for Wound Healing, and The Australian Wound Management Association.