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引用次数: 0
摘要
晶体物质可引起多种急性和慢性炎症性疾病，如痛风性关节炎、矽肺、肾病和动脉粥样硬化。各种类型的晶体被认为会引起类似的炎症反应，包括释放促炎症介质和形成中性粒细胞胞外陷阱（NET），这些过程会进一步促进坏死性炎症和组织损伤。显而易见的是，晶体相关疾病的炎症强度以及 NET 形成和中性粒细胞死亡的相关机制会因晶体类型、数量和沉积部位的不同而不同。这篇综述详细介绍了晶体生物学的新机理，强调了各种晶体对中性粒细胞和细胞外陷阱（ET）形成的不同影响，并讨论了晶体相关疾病的治疗策略和未来的潜在方法。
Neutrophils and extracellular traps in crystal-associated diseases.
Crystalline material can cause a multitude of acute and chronic inflammatory diseases, such as gouty arthritis, silicosis, kidney disease, and atherosclerosis. Crystals of various types are thought to cause similar inflammatory responses, including the release of proinflammatory mediators and formation of neutrophil extracellular traps (NETs), processes that further promote necroinflammation and tissue damage. It has become apparent that the intensity of inflammation and the related mechanisms of NET formation and neutrophil death in crystal-associated diseases can vary depending on the crystal type, amount, and site of deposition. This review details new mechanistic insights into crystal biology, highlights the differential effects of various crystals on neutrophils and extracellular trap (ET) formation, and discusses treatment strategies and potential future approaches for crystal-associated disorders.
期刊介绍：
Trends in Molecular Medicine (TMM) aims to offer concise and contextualized perspectives on the latest research advancing biomedical science toward better diagnosis, treatment, and prevention of human diseases. It focuses on research at the intersection of basic biology and clinical research, covering new concepts in human biology and pathology with clear implications for diagnostics and therapy. TMM reviews bridge the gap between bench and bedside, discussing research from preclinical studies to patient-enrolled trials. The major themes include disease mechanisms, tools and technologies, diagnostics, and therapeutics, with a preference for articles relevant to multiple themes. TMM serves as a platform for discussion, pushing traditional boundaries and fostering collaboration between scientists and clinicians. The journal seeks to publish provocative and authoritative articles that are also accessible to a broad audience, inspiring new directions in molecular medicine to enhance human health.
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