黄芪有效成分对糖尿病肾病的保护作用的可能机制。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-06-10 DOI:10.1080/10286020.2024.2364350

Yu Li, Jing Wang

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引用次数: 0

摘要

黄芪（Aragali Radix，AR）是一种常见的中药材，大量研究表明其对糖尿病肾病（DN）具有保护作用。为了总结黄芪对糖尿病肾病的最新药理作用，我们收集并查阅了 PubMed 上有关黄芪的文章。AR 保护作用的作用机制与糖尿病肾病实验模型中的抗纤维化、抗炎、抗氧化应激、抗结节细胞凋亡、线粒体功能恢复、内皮功能恢复有关。因此，AR有望成为治疗糖尿病肾病的潜在新型疗法。

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Possible mechanism for the protective effect of active ingredients of astragalus membranaceus on diabetes nephropathy.

Astragali Radix (AR), a common traditional Chinese medicinal herb, exhibits protective effects on diabetic nephropathy (DN) in extensive researches. Aticles focusing on AR in PubMed were collected and reviewed in order to summarize the latest pharmacological effects on DN. The action mechanisms for protectiving effects of AR were associated with regulation of anti-fibrosis, anti-inflammation, anti-oxidative stress, anti-podocyte apoptosis, restoration of mitochondrial function, restoration of endothelial function in diabetes nephropathy experimental models. Consequently, AR hold promise as potential novel therapeutics for the treatment of DN.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.