轻度认知障碍可预测肌肉疏松症的发病:英国老龄化纵向研究的纵向分析。

IF 3.4 3区 医学 Q2 GERIATRICS & GERONTOLOGY
Francesco Saverio Ragusa, Nicola Veronese, Laura Vernuccio, Ligia J Dominguez, Lee Smith, Francesco Bolzetta, Ai Koyanagi, Roberto Monastero, Mario Barbagallo
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引用次数: 0

摘要

背景:轻度认知障碍(MCI)和肌肉疏松症是老年人的两种常见病。MCI 能否预测肌肉疏松症的发病,目前还不为人们所广泛知晓。因此,我们旨在研究 MCI 能否预测老年人群中肌肉疏松症的发生:在 ELSA(英国老龄化纵向研究)中,MCI 被定义为无痴呆症、功能保持正常以及在三项客观认知测试中表现较差。在随访期间,手握力和骨骼肌质量指数较低即可诊断为 "肌肉疏松症"。我们使用多变量逻辑回归模型评估了基线MCI与肌肉疏松症之间的纵向联系,并以调整后的几率比(OR)和95%置信区间(95%CI)报告数据:共纳入 3106 名参与者(平均年龄为 63.1 岁;55.3% 为男性)。MCI患者的平均手握力值和骨骼质量指数(SMI)明显较低,基线肥胖率也较高。基线时有 729 人患有 MCI,在十年的随访期间,12.1% 的初始人群患有肌肉疏松症。在对18种潜在混杂因素进行调整的多变量分析中,MCI(OR=1.236;95%CI:1.090-1.596,p=0.01)显著预测了随访期间肌肉疏松症的发病率:结论:基线时存在 MCI 与十年随访期间较高的肌肉疏松症发病率有关,这表明 MCI 可能是老年人肌肉疏松症发病的一个预测因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Mild cognitive impairment predicts the onset of Sarcopenia: a longitudinal analysis from the English Longitudinal Study on Ageing.

Mild cognitive impairment predicts the onset of Sarcopenia: a longitudinal analysis from the English Longitudinal Study on Ageing.

Background: Mild cognitive impairment (MCI) and sarcopenia are two common conditions in older people. It is not widely known if MCI could predict the onset of sarcopenia. Therefore, we aimed to investigate whether MCI could predict the occurrence of sarcopenia in a population of older adults.

Methods: In the ELSA (English Longitudinal Study on Ageing), MCI was defined as the absence of dementia, preserved functional capacity and low performance in three objective cognitive tests. Sarcopenia was diagnosed as having low handgrip strength and low skeletal muscle mass index during follow-up. The longitudinal association between MCI at the baseline and incident sarcopenia was assessed using a multivariable logistic regression model, reporting the data as adjusted odds ratios (OR) and 95% confidence intervals (95%CI).

Results: 3,106 participants (mean age of 63.1 years; 55.3% males) were included. People with MCI reported significantly lower mean handgrip strength values and Skeletal Mass Index (SMI), as well as a higher prevalence of obesity at baseline. At baseline, 729 people had MCI and during the ten years follow-up period, 12.1% of the initial population included had sarcopenia. On multivariate analysis, adjusted for 18 potential confounders, the presence of MCI (OR = 1.236; 95%CI: 1.090-1.596, p = 0.01) significantly predicted the onset of sarcopenia during follow-up.

Conclusion: The presence of MCI at baseline was associated with a higher incidence of sarcopenia at ten-years follow-up, demonstrating a likely role of MCI as a predictor of the onset of sarcopenia in older people.

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来源期刊
CiteScore
7.90
自引率
5.00%
发文量
283
审稿时长
1 months
期刊介绍: Aging clinical and experimental research offers a multidisciplinary forum on the progressing field of gerontology and geriatrics. The areas covered by the journal include: biogerontology, neurosciences, epidemiology, clinical gerontology and geriatric assessment, social, economical and behavioral gerontology. “Aging clinical and experimental research” appears bimonthly and publishes review articles, original papers and case reports.
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