过敏性鼻炎与角膜炎：系统回顾与荟萃分析。

IF 8.2 1区医学 Q1 ALLERGY

Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2024-11-01 DOI:10.1016/j.jaip.2024.05.050

Jui-En Lo MD , Yen-Hsi Huang MD , Neil Bhattacharyya MD, FACS , Eric Alan Moulton OD, PhD , Kevin Sheng-Kai Ma DDS, FRSPH, FRSM

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引用次数: 0

摘要

背景：角膜炎与各种过敏性疾病之间的关系一直存在争议：角膜塑形镜与各种过敏性疾病之间的关系一直存在争议：本研究对过敏性鼻炎（AR）与角膜炎之间的关系进行了系统回顾和荟萃分析：方法：系统回顾了 PubMed、Web of Science 和 Cochrane Library 中符合条件的相关研究，以评估 AR 与角膜炎之间的关联。纳入的观察性研究包含角膜病患者和非角膜病患者的人数，以及被诊断出患有或未患有 AR 的角膜病患者的人数。两名审稿人独立筛选符合条件的研究，并从纳入的研究中提取数据。我们进行了一项双变量荟萃分析，以比较有 AR 和无 AR 患者发生角膜炎的几率。主要结果是有 AR 患者发生角膜炎的几率。为了验证研究结果，使用纳入研究中报告的调整后几率进行了敏感性测试：本次荟萃分析共纳入了七项研究，涉及 775,574 名参与者。其中，29082 名患者患有角膜炎。AR患者发生角膜炎的汇总几率比为1.71（95%置信区间[CI]：1.36-2.15；P < 0.001；I2 = 96%），汇总调整几率比为1.72（95% CI：1.23-2.40；P = 0.001；I2 = 97%）：结论：有AR的患者发生角膜炎的几率明显高于无AR的患者。今后有必要开展研究，以调查因果关系，并评估使用角膜地形图等方法进行早期筛查和转诊角膜塑形镜患者的成本效益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Allergic Rhinitis and Keratoconus: A Systematic Review and Meta-Analysis

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Allergic Rhinitis and Keratoconus: A Systematic Review and Meta-Analysis

Background

The relationship between keratoconus and various allergic diseases has been a subject of controversy.

Objective

In the present study, a systematic review and meta-analysis was conducted to investigate the association between allergic rhinitis (AR) and keratoconus.

Methods

Relevant and eligible studies from PubMed, Web of Science, and the Cochrane Library were systematically reviewed to evaluate the association between AR and keratoconus. Observational studies that reported the number of patients with and without keratoconus, as well as the number of patients with keratoconus diagnosed with or without AR, were included. Two reviewers independently screened eligible studies and extracted data. A bivariate meta-analysis was conducted to calculate the pooled odds ratio of keratoconus in patients with versus without AR. A sensitivity analysis was performed using the adjusted odds ratio reported in the included studies to validate the findings.

Results

Seven studies involving 775,574 participants were included in the meta-analysis. Among them, 29,082 patients had keratoconus. The pooled odds ratio of keratoconus in patients with AR was 1.71 (95% confidence interval [CI]: 1.36-2.15; P < .001; I² = 96%), and the pooled adjusted odds ratio was 1.72 (95% CI: 1.23-2.40; P = .001; I² = 97%).

Conclusions

Patients with AR have significantly higher odds of keratoconus than those without AR. Future studies are warranted to investigate the causal relationship and evaluate the cost-effectiveness of early screening, using methods such as corneal topography, and referral for keratoconus in patients with AR.

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来源期刊

Journal of Allergy and Clinical Immunology-In Practice ALLERGYIMMUNOLOGY-IMMUNOLOGY

CiteScore

11.10

自引率

9.60%

发文量

683

审稿时长

50 days

期刊介绍： JACI: In Practice is an official publication of the American Academy of Allergy, Asthma & Immunology (AAAAI). It is a companion title to The Journal of Allergy and Clinical Immunology, and it aims to provide timely clinical papers, case reports, and management recommendations to clinical allergists and other physicians dealing with allergic and immunologic diseases in their practice. The mission of JACI: In Practice is to offer valid and impactful information that supports evidence-based clinical decisions in the diagnosis and management of asthma, allergies, immunologic conditions, and related diseases. This journal publishes articles on various conditions treated by allergist-immunologists, including food allergy, respiratory disorders (such as asthma, rhinitis, nasal polyps, sinusitis, cough, ABPA, and hypersensitivity pneumonitis), drug allergy, insect sting allergy, anaphylaxis, dermatologic disorders (such as atopic dermatitis, contact dermatitis, urticaria, angioedema, and HAE), immunodeficiency, autoinflammatory syndromes, eosinophilic disorders, and mast cell disorders. The focus of the journal is on providing cutting-edge clinical information that practitioners can use in their everyday practice or to acquire new knowledge and skills for the benefit of their patients. However, mechanistic or translational studies without immediate or near future clinical relevance, as well as animal studies, are not within the scope of the journal.