减肥期间膝骨关节炎患者大腿肌肉成分的变化：利用骨关节炎倡议组织的数据进行性别特异性分析。

IF 7.2 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage Pub Date : 2024-06-06 DOI:10.1016/j.joca.2024.05.013

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引用次数: 0

摘要

目的：膝关节骨性关节炎（KOA）患者的性别可能会影响减肥过程中大腿肌肉成分的变化，而减肥是最著名的疾病调整干预措施。我们研究了膝关节骨性关节炎患者在减肥过程中大腿肌肉质量的纵向性别变化：利用骨关节炎倡议（OAI）队列数据，我们纳入了基线放射学 KOA 患者中体重指数在四年内下降>5%的女性和男性。利用之前验证的深度学习算法，我们测量了基线和第四年大腿肌肉的 MRI 衍生生物标记物。结果是女性和男性大腿肌肉的肌内和肌间脂肪组织（Intra-MAT 和 Inter-MAT）以及收缩百分比。分析调整了潜在的混杂因素，如人口统计学、风险因素、体重指数变化、体力活动、饮食和 KOA 状态：通过对体重减轻 4 年（体重指数大于 5%）的 KOA 参与者的大腿核磁共振成像进行回顾性筛选，得到了 313 个大腿样本（女性 192 个，男性 121 个）。女性和男性参与者的体重减轻程度相当（女性：-9.72±4.38，男性：-8.83±3.64，P 值=0.060）。然而，与男性相比，女性大腿肌肉质量的变化并不那么有利，这表现在大腿肌肉内径（Intra-MAT）的纵向减少程度较小（变化差异，95%CI：783.44 mm2/4-year，505.70 至 1061.19，P-value）：在 KOA 和 4 年体重减轻的参与者中，大腿肌肉质量的纵向变化总体上是有益的，但与男性相比，女性大腿肌肉质量的纵向变化程度较低。有必要进一步研究其潜在机制，并制定针对不同性别的干预措施，以优化减肥期间的肌肉质量。

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Thigh muscle composition changes in knee osteoarthritis patients during weight loss: Sex-specific analysis using data from osteoarthritis initiative

Objectives

Sex of patients with knee osteoarthritis (KOA) may impact changes in thigh muscle composition during weight loss, the most well-known disease-modifying intervention. We investigated longitudinal sex-based changes in thigh muscle quality during weight loss in participants with KOA.

Methods

Using Osteoarthritis Initiative (OAI) cohort data, we included females and males with baseline radiographic KOA who experienced > 5 % reduction in Body Mass Index (BMI) over four years. Using a previously validated deep-learning algorithm, we measured Magnetic Resonance Imaging (MRI)-derived biomarkers of thigh muscles at baseline and year-4. Outcomes were the intra- and inter-muscular adipose tissue (Intra-MAT and Inter-MAT) and contractile percentage of thigh muscles between females and males. The analysis adjusted for potential confounders, such as demographics, risk factors, BMI change, physical activity, diet, and KOA status.

Results

A retrospective selection of available thigh MRIs from KOA participants who also had a 4-year weight loss (>5 % of BMI) yielded a sample comprising 313 thighs (192 females and 121 males). Female and male participants exhibited a comparable degree of weight loss (females: −9.72 ± 4.38, males: −8.83 ± 3.64, P-value=0.060). However, the changes in thigh muscle quality were less beneficial for females compared to males, as shown by a less degree of longitudinal decrease in Intra-MAT (change difference,95 %CI: 783.44 mm²/4-year, 505.70 to 1061.19, P-value<0.001) and longitudinal increase in contractile percentage (change difference,95 %CI: −3.9 %/4-year, −6.5 to −1.4, P-value=0.019).

Conclusions

In participants with KOA and 4-year weight loss, the longitudinal changes in thigh muscle quality were overall beneficial but to a less degree in females compared to males. Further research is warranted to investigate the underlying mechanisms and develop sex-specific interventions to optimize muscle quality during weight loss.

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来源期刊

Osteoarthritis and Cartilage 医学-风湿病学

CiteScore

11.70

自引率

7.10%

发文量

802

审稿时长

52 days

期刊介绍： Osteoarthritis and Cartilage is the official journal of the Osteoarthritis Research Society International. It is an international, multidisciplinary journal that disseminates information for the many kinds of specialists and practitioners concerned with osteoarthritis.