多孔 PVA 水凝胶涂层的压缩模量对防止聚丙烯网格粘附的影响

IF 4.4 4区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Dandan Wei, Yulin Huang, Pengfei Ren, Min Liang, Li Xu, Liuxin Yang, Tianzhu Zhang, Zhenling Ji
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引用次数: 0

摘要

PP 网片是一种广泛用于疝修补的假体材料。然而,内脏粘连是该手术最严重的并发症之一。因此,通过冻融法在聚丙烯表面涂覆多孔聚乙烯醇(PVA)水凝胶,开发了一种防粘聚丙烯网。首先通过在 PVA 中加入不同质量比的成孔剂碳酸氢钠(NaHCO3)来调节多孔 PVA 水凝胶涂层的压缩模量。不出所料,多孔水凝胶涂层显示出更接近于原生腹壁组织的模量。体外测试表明,改性聚丙烯网状材料具有卓越的涂层稳定性、良好的血液相容性和细胞相容性。体内实验表明,模仿原生腹壁模量的 PVA4 水凝胶包覆的 PP 网片能有效防止粘连。在此基础上,在多孔 PVA4 水凝胶涂层中加入雷帕霉素(RPM),进一步提高了 PP 网片的防粘连性能。血红素和伊红(H&E)以及马森三色染色(MT)结果证实,所制成的网片可以减轻炎症反应,并减少植入区周围胶原蛋白的沉积。改性聚丙烯网片的仿生物机械性能和抗粘连性能使其成为疝成形术中的重要候选材料。本文受版权保护。保留所有权利。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of Compressive Modulus of Porous PVA Hydrogel Coating on the Preventing Adhesion of Polypropylene Mesh

PP mesh is a widely used prosthetic material in hernia repair. However, visceral adhesion is one of the worst complications of this operation. Hence, an anti-adhesive PP mesh is developed by coating porous polyvinyl alcohol (PVA) hydrogel on PP surface via freezing-thawing process method. The compressive modulus of porous PVA hydrogel coating is first regulated by the addition of porogen sodium bicarbonate (NaHCO3) at various quality ratios with PVA. As expected, the porous hydrogel coating displayed modulus more closely resembling that of native abdominal wall tissue. In vitro tests demonstrate the modified PP mesh show superior coating stability, excellent hemocompatibility, and good cytocompatibility. In vivo experiments illustrate that PP mesh coated by the PVA4 hydrogel that mimicked the modulus of native abdominal wall could prevent adhesion effectively. Based on this, the rapamycin (RPM) is loaded into the porous PVA4 hydrogel coating to further improve anti-adhesive property of PP mesh. The Hematoxylin and eosin (H&E) and Masson trichrome (MT) staining results verified that the resulting mesh could alleviate the inflammation response and reduce the deposition of collagen around the implantation zone. The biomimetic mechanical property and anti-adhesive property of modified PP mesh make it a valuable candidate for application in hernioplasty.

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来源期刊
Macromolecular bioscience
Macromolecular bioscience 生物-材料科学:生物材料
CiteScore
7.90
自引率
2.20%
发文量
211
审稿时长
1.5 months
期刊介绍: Macromolecular Bioscience is a leading journal at the intersection of polymer and materials sciences with life science and medicine. With an Impact Factor of 2.895 (2018 Journal Impact Factor, Journal Citation Reports (Clarivate Analytics, 2019)), it is currently ranked among the top biomaterials and polymer journals. Macromolecular Bioscience offers an attractive mixture of high-quality Reviews, Feature Articles, Communications, and Full Papers. With average reviewing times below 30 days, publication times of 2.5 months and listing in all major indices, including Medline, Macromolecular Bioscience is the journal of choice for your best contributions at the intersection of polymer and life sciences.
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