Stanislav Vovdenko, Stanislav Ali, Hussein Ali, Mark Taratkin, Andrey Morozov, Aleksandr Suvorov, Diana Khabib, Leonid Rapoport, Evgeny Bezrukov
{"title":"对比增强超声（CEUS）作为肾肿瘤病灶治疗后的随访方法：系统综述和荟萃分析。","authors":"Stanislav Vovdenko, Stanislav Ali, Hussein Ali, Mark Taratkin, Andrey Morozov, Aleksandr Suvorov, Diana Khabib, Leonid Rapoport, Evgeny Bezrukov","doi":"10.1007/s11255-024-04102-9","DOIUrl":null,"url":null,"abstract":"<p><strong>Context: </strong>Contrast-enhanced ultrasound (CEUS) is a cost-effective radiation-free diagnostic method that can be used for renal tumor postoperative visualization after ablative treatment.</p><p><strong>Objective: </strong>To assess CEUS diagnostic accuracy comparing with CT and MRI as a follow-up method in short-term and long-term postoperative periods after renal tumor ablation.</p><p><strong>Materials and methods: </strong>A systematic review and meta-analysis were performed in Scopus and Medline databases using the query \"(kidney OR rena* OR RCC) AND (ablation OR RFA OR MWA OR cryo*) AND CEUS\". The endpoint of the study was the evaluation of the overall accuracy of CEUS.</p><p><strong>Results: </strong>Twelve trials were included in the review. With CT or MRI as a reference, for a short-term group (< 6 weeks after ablation) pooled sensitivity was 90.2%, I<sup>2</sup> = 0%; pooled specificity was 99.3%, I<sup>2</sup> = 0%; pooled NPV was 98.6%, I<sup>2</sup> = 0%; pooled PPV was 94.6%, I<sup>2</sup> = 0%; the AUC on the SROC curve was 0.971. For the long-term group (> 6 weeks after ablation), pooled sensitivity was 95.3%, I<sup>2</sup> = 0%; pooled specificity was 97.6%, I<sup>2</sup> = 0%; PPV was 74.2%, I<sup>2</sup> = 4%; NPV was 99.4%, I<sup>2</sup> = 5%; AUC = 0.93.</p><p><strong>Conclusion: </strong>CEUS has high sensitivity and specificity in ruling out the presence of local recurrence after renal tumor ablation with a higher risk of false-positive results within follow-up > 6 weeks compared with that for CT or MRI. Further studies with a unified protocol and morphological control of local renal tumor recurrence after ablation are needed.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"3415-3426"},"PeriodicalIF":1.8000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Contrast-enhanced ultrasound (CEUS) as a follow-up method after the focal treatment of renal tumors: systematic review and meta-analysis.\",\"authors\":\"Stanislav Vovdenko, Stanislav Ali, Hussein Ali, Mark Taratkin, Andrey Morozov, Aleksandr Suvorov, Diana Khabib, Leonid Rapoport, Evgeny Bezrukov\",\"doi\":\"10.1007/s11255-024-04102-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Context: </strong>Contrast-enhanced ultrasound (CEUS) is a cost-effective radiation-free diagnostic method that can be used for renal tumor postoperative visualization after ablative treatment.</p><p><strong>Objective: </strong>To assess CEUS diagnostic accuracy comparing with CT and MRI as a follow-up method in short-term and long-term postoperative periods after renal tumor ablation.</p><p><strong>Materials and methods: </strong>A systematic review and meta-analysis were performed in Scopus and Medline databases using the query \\\"(kidney OR rena* OR RCC) AND (ablation OR RFA OR MWA OR cryo*) AND CEUS\\\". The endpoint of the study was the evaluation of the overall accuracy of CEUS.</p><p><strong>Results: </strong>Twelve trials were included in the review. With CT or MRI as a reference, for a short-term group (< 6 weeks after ablation) pooled sensitivity was 90.2%, I<sup>2</sup> = 0%; pooled specificity was 99.3%, I<sup>2</sup> = 0%; pooled NPV was 98.6%, I<sup>2</sup> = 0%; pooled PPV was 94.6%, I<sup>2</sup> = 0%; the AUC on the SROC curve was 0.971. For the long-term group (> 6 weeks after ablation), pooled sensitivity was 95.3%, I<sup>2</sup> = 0%; pooled specificity was 97.6%, I<sup>2</sup> = 0%; PPV was 74.2%, I<sup>2</sup> = 4%; NPV was 99.4%, I<sup>2</sup> = 5%; AUC = 0.93.</p><p><strong>Conclusion: </strong>CEUS has high sensitivity and specificity in ruling out the presence of local recurrence after renal tumor ablation with a higher risk of false-positive results within follow-up > 6 weeks compared with that for CT or MRI. Further studies with a unified protocol and morphological control of local renal tumor recurrence after ablation are needed.</p>\",\"PeriodicalId\":14454,\"journal\":{\"name\":\"International Urology and Nephrology\",\"volume\":\" \",\"pages\":\"3415-3426\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Urology and Nephrology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s11255-024-04102-9\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/6/8 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"UROLOGY & NEPHROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Urology and Nephrology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11255-024-04102-9","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/8 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
Contrast-enhanced ultrasound (CEUS) as a follow-up method after the focal treatment of renal tumors: systematic review and meta-analysis.
Context: Contrast-enhanced ultrasound (CEUS) is a cost-effective radiation-free diagnostic method that can be used for renal tumor postoperative visualization after ablative treatment.
Objective: To assess CEUS diagnostic accuracy comparing with CT and MRI as a follow-up method in short-term and long-term postoperative periods after renal tumor ablation.
Materials and methods: A systematic review and meta-analysis were performed in Scopus and Medline databases using the query "(kidney OR rena* OR RCC) AND (ablation OR RFA OR MWA OR cryo*) AND CEUS". The endpoint of the study was the evaluation of the overall accuracy of CEUS.
Results: Twelve trials were included in the review. With CT or MRI as a reference, for a short-term group (< 6 weeks after ablation) pooled sensitivity was 90.2%, I2 = 0%; pooled specificity was 99.3%, I2 = 0%; pooled NPV was 98.6%, I2 = 0%; pooled PPV was 94.6%, I2 = 0%; the AUC on the SROC curve was 0.971. For the long-term group (> 6 weeks after ablation), pooled sensitivity was 95.3%, I2 = 0%; pooled specificity was 97.6%, I2 = 0%; PPV was 74.2%, I2 = 4%; NPV was 99.4%, I2 = 5%; AUC = 0.93.
Conclusion: CEUS has high sensitivity and specificity in ruling out the presence of local recurrence after renal tumor ablation with a higher risk of false-positive results within follow-up > 6 weeks compared with that for CT or MRI. Further studies with a unified protocol and morphological control of local renal tumor recurrence after ablation are needed.
期刊介绍：
International Urology and Nephrology publishes original papers on a broad range of topics in urology, nephrology and andrology. The journal integrates papers originating from clinical practice.
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