一名接受 PD-1 治疗的晚期非小细胞肺癌患者的甲状腺无节细胞癌转化：病例报告

IF 0.8 Q4 RESPIRATORY SYSTEM

Respiratory Medicine Case Reports Pub Date : 2024-01-01 DOI:10.1016/j.rmcr.2024.102070

Yoko Kataoka , Takuya Fujita , Jun Hanaoka

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引用次数: 0

摘要

关于肺癌免疫治疗期间其他器官发生肿瘤性转化的报道很少。我们报告了一例 71 岁男性患者的病例，他被诊断出患有晚期肺腺癌和甲状腺肿瘤。患者对化放疗有反应，但肺转移复发。因此，患者开始接受 nivolumab 治疗，并获得了肺转移完全应答。32个nivolumab周期后，患者出现颈部疼痛，甲状腺肿瘤迅速增大。组织学检查显示为甲状腺无节细胞癌。肺癌免疫治疗虽然罕见，但有可能诱发其他器官的肿瘤转化。

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Anaplastic thyroid carcinoma transformation in a patient with advanced non-small cell lung cancer treated with PD-1 therapy: A case report

There have rarely been reports on the neoplastic transformation in other organs during immunotherapy for lung cancer. We report the case of a 71-year-old man who was diagnosed with advanced pulmonary adenocarcinoma and a thyroid tumor. The patient responded to chemoradiotherapy but developed a recurrence of pulmonary metastasis. Therefore, nivolumab was started, and a complete response for pulmonary metastasis was achieved. After 32 nivolumab cycles, he experienced neck pain, and the thyroid tumor grew rapidly. Histological examination revealed anaplastic thyroid carcinoma. Although rare, immunotherapy for lung cancer has the potential to induce neoplastic transformation in other organs.

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