一例肺腺癌伴同步单发脑转移患者经综合治疗后获得完全病理反应的病例

IF 0.8 Q4 RESPIRATORY SYSTEM

Respiratory Medicine Case Reports Pub Date : 2024-01-01 DOI:10.1016/j.rmcr.2024.102060

Tomoya Tajiri, Keigo Sekihara, Motohisa Shibata, Takamitsu Hayakawa, Akikazu Kawase, Norihiko Shiiya, Kazuhito Funai

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引用次数: 0

摘要

全身化疗是治疗有远处转移的非小细胞肺癌的标准疗法。然而，对于有同步单发脑转移（SSBM）的患者，建议对脑和胸部病灶进行额外的局部治疗。我们报告了一例被诊断为肺腺癌和 SSBM 的 71 岁男性病例。脑转移瘤的病理检查显示，程序性细胞死亡配体 1 的免疫染色呈阳性表达。经过四个周期的免疫检查点抑制剂化疗后，患者接受了右上叶 ND2a-1 切除术。病理检查显示病理反应完全，该患者有望获得长期生存。

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A case of complete pathological response after comprehensive treatment in a patient with pulmonary adenocarcinoma with synchronous solitary brain metastasis

Systemic chemotherapy is the standard treatment for non-small cell lung cancer with distant metastases. However, additional local treatment for brain and thoracic lesions is recommended for patients with synchronous solitary brain metastases (SSBM). We report the case of a 71-year-old male diagnosed with pulmonary adenocarcinoma and SSBM. Pathological examination of the brain metastasis showed positive immunostaining for programmed cell death ligand 1 expression. After four cycles of chemotherapy with immune checkpoint inhibitors, right upper lobectomy with ND2a-1 was performed. Pathological examination revealed complete pathological response, and this patient is expected to experience long-term survival.

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