以沸石 Y 为载体的生物合成柿皮银纳米粒子作为生物相容性抗菌剂，对抗痤疮杆菌

IF 4.1 2区材料科学 Q2 ENGINEERING, CHEMICAL

Particuology Pub Date : 2024-05-31 DOI:10.1016/j.partic.2024.05.015

Muhammad Hariz Asraf , Nik Ahmad Nizam Nik Malek , Muhammad Redza Mohd Radzi , Hendra Susanto

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引用次数: 0

摘要

传统合成的纳米银粒子（AgNP）对环境造成了令人担忧的影响，并对人体产生毒性。然而，使用沸石（zeoY）作为支撑系统可以增加其生物相容性并降低其毒性。因此，我们采用原位合成技术，以沸石 Y 为支撑，利用柿叶提取物绿色合成了 AgNP。优化后的叶提取物浓度为 1%，体积为 0.9 mL，其中的植物化学物质可将沸石 Y 孔隙中的银离子还原成 AgNP。形态学观察显示，沸石 Y 中含有 AgNP（平均尺寸：18.51 nm）。释放出的 AgNP 在浓度低于 1 g L-1 时对痤疮丙酸杆菌具有抗菌活性，这也与电解质有关。AgNP-zeoY 在体外可促进细胞增殖，在体内皮肤刺激模型测试中也没有刺激作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Biosynthesized Persicaria odorata-silver nanoparticles supported zeolite Y as biocompatible antibacterial agent against Cutibacterium acnes

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Biosynthesized Persicaria odorata-silver nanoparticles supported zeolite Y as biocompatible antibacterial agent against Cutibacterium acnes

Conventionally synthesized silver nanoparticles (AgNP) imposed an alarming effect on the environment and caused toxicity to humans. However, the use of zeolite (zeoY) as a support system could increase its biocompatibility and reduce its toxicity. Hence, green synthesis of AgNP using Persicaria odorata leaves extract supported on zeolite Y has been prepared by an in situ synthesis technique. The phytochemical compounds in the optimized leaf extract concentration of 1% and volume of 0.9 mL reduced the silver ions to AgNP within the zeolite Y pores. Morphological observation revealed the incorporation of AgNP in the zeolite Y (average size: 18.51 nm). The release of AgNP exhibited antibacterial activity on C. acnes at a concentration lower than 1 g L⁻¹ which is also dependent on the electrolyte. AgNP-zeoY promoted cell proliferation in vitro and it has a non-irritating effect when tested in the in vivo skin irritation model.

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来源期刊

Particuology 工程技术-材料科学：综合

CiteScore

6.70

自引率

2.90%

发文量

1730

审稿时长

32 days

期刊介绍： The word ‘particuology’ was coined to parallel the discipline for the science and technology of particles. Particuology is an interdisciplinary journal that publishes frontier research articles and critical reviews on the discovery, formulation and engineering of particulate materials, processes and systems. It especially welcomes contributions utilising advanced theoretical, modelling and measurement methods to enable the discovery and creation of new particulate materials, and the manufacturing of functional particulate-based products, such as sensors. Papers are handled by Thematic Editors who oversee contributions from specific subject fields. These fields are classified into: Particle Synthesis and Modification; Particle Characterization and Measurement; Granular Systems and Bulk Solids Technology; Fluidization and Particle-Fluid Systems; Aerosols; and Applications of Particle Technology. Key topics concerning the creation and processing of particulates include: -Modelling and simulation of particle formation, collective behaviour of particles and systems for particle production over a broad spectrum of length scales -Mining of experimental data for particle synthesis and surface properties to facilitate the creation of new materials and processes -Particle design and preparation including controlled response and sensing functionalities in formation, delivery systems and biological systems, etc. -Experimental and computational methods for visualization and analysis of particulate system. These topics are broadly relevant to the production of materials, pharmaceuticals and food, and to the conversion of energy resources to fuels and protection of the environment.