溶酶体对 cGAS-STING 信号转导的控制。

IF 13 1区生物学 Q1 CELL BIOLOGY

Trends in Cell Biology Pub Date : 2024-08-01 Epub Date: 2024-06-06 DOI:10.1016/j.tcb.2024.05.004

Yinfeng Xu, Wei Wan

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引用次数: 0

摘要

环GMP-AMP（cGAMP）合成酶（cGAS）-干扰素基因刺激器（STING）通路在对抗病原体感染方面发挥着至关重要的作用。然而，它的异常激活与多种人类疾病有关。溶酶体正在成为 cGAS-STING 信号转导的关键负调控因子。在此，我们将讨论溶酶体对 cGAS-STING 信号转导的控制及其对人类疾病的影响。

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Lysosomal control of the cGAS-STING signaling.

The cyclic GMP-AMP (cGAMP) synthase (cGAS)-stimulator of interferon genes (STING) pathway has a crucial role in combating pathogen infection. However, its aberrant activation is involved in several human disorders. Lysosomes are emerging as key negative regulators of cGAS-STING signaling. Here, we discuss the lysosomal control of cGAS-STING signaling and its implication in human disorders.

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来源期刊

Trends in Cell Biology 生物-细胞生物学

CiteScore

32.00

自引率

0.50%

发文量

160

审稿时长

61 days

期刊介绍： Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.