拥抱复杂性:新型测序方法对疱疹病毒基因组多样性的启示》(What Novel Sequencing Methods Are Teaching Us About Herpesvirus Genomic Diversity.

IF 8.1 1区 医学 Q1 VIROLOGY
Annual Review of Virology Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI:10.1146/annurev-virology-100422-010336
Alejandro Ortigas-Vasquez, Moriah Szpara
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引用次数: 0

摘要

过去二十年中,新型测序技术的出现使我们对疱疹病毒基因组多样性的认识发生了范式转变。以前,人们认为疱疹病毒是 DNA 病毒家族的一种,其基因组大多相同,进化速度比 RNA 病毒慢得多。然而,现在越来越多的证据表明,疱疹病毒是作为动态种群存在的,它们拥有恒定的变异,进化速度比以前假设的要快得多。在这篇综述中,我们将探讨深度测序、长序列测序和单体型重建等策略是如何让科学家们剖析疱疹病毒种群的基因组组成的。我们还讨论了在详细了解疱疹病毒多样性之前需要应对的挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Embracing Complexity: What Novel Sequencing Methods Are Teaching Us About Herpesvirus Genomic Diversity.

The arrival of novel sequencing technologies throughout the past two decades has led to a paradigm shift in our understanding of herpesvirus genomic diversity. Previously, herpesviruses were seen as a family of DNA viruses with low genomic diversity. However, a growing body of evidence now suggests that herpesviruses exist as dynamic populations that possess standing variation and evolve at much faster rates than previously assumed. In this review, we explore how strategies such as deep sequencing, long-read sequencing, and haplotype reconstruction are allowing scientists to dissect the genomic composition of herpesvirus populations. We also discuss the challenges that need to be addressed before a detailed picture of herpesvirus diversity can emerge.

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来源期刊
CiteScore
19.40
自引率
0.90%
发文量
28
期刊介绍: The Annual Review of Virology serves as a conduit for disseminating thrilling advancements in our comprehension of viruses spanning animals, plants, bacteria, archaea, fungi, and protozoa. Its reviews illuminate novel concepts and trajectories in basic virology, elucidating viral disease mechanisms, exploring virus-host interactions, and scrutinizing cellular and immune responses to virus infection. These reviews underscore the exceptional capacity of viruses as potent probes for investigating cellular function.
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