Martín Alcorlo, Siseth Martínez-Caballero, Jianwei Li, Lok-To Sham, Min Luo, Juan A Hermoso
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引用次数: 0
摘要
FtsEX 膜复合体是 ABC 转运体超家族的重要组成部分，广泛分布于细菌物种中。它控制着细胞分裂所需的肽聚糖降解，是一种信号传递器，而不是底物转运器。通过 FtsE 的 ATP 酶活性，它能促进信号从细胞膜传递到外质，激活相关的肽聚糖水解酶。这篇综述集中探讨了最新的结构进展，阐明了 FtsEX 复合物的结构及其与溶解酶或调控对应物的相互作用。所揭示的三维结构揭示了一幅图景，在这幅图景中，一系列精确的分子间相互作用在不同的细菌物种中得以保留，对细胞分裂过程进行了细致的空间和时间控制。
Modulation of the lytic apparatus by the FtsEX complex within the bacterial division machinery.
The FtsEX membrane complex constitutes an essential component of the ABC transporter superfamily, widely distributed among bacterial species. It governs peptidoglycan degradation for cell division, acting as a signal transmitter rather than a substrate transporter. Through the ATPase activity of FtsE, it facilitates signal transmission from the cytosol across the membrane to the periplasm, activating associated peptidoglycan hydrolases. This review concentrates on the latest structural advancements elucidating the architecture of the FtsEX complex and its interplay with lytic enzymes or regulatory counterparts. The revealed three-dimensional structures unveil a landscape wherein a precise array of intermolecular interactions, preserved across diverse bacterial species, afford meticulous spatial and temporal control over the cell division process.
期刊介绍：
FEBS Letters is one of the world''s leading journals in molecular biology and is renowned both for its quality of content and speed of production. Bringing together the most important developments in the molecular biosciences, FEBS Letters provides an international forum for Minireviews, Research Letters and Hypotheses that merit urgent publication.
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