口腔粘膜疾病（OMD）患者的维生素 B12 水平：系统性综述

Q3 Nursing

Clinical Nutrition Open Science Pub Date : 2024-05-28 DOI:10.1016/j.nutos.2024.05.011

Nadia Tiara Putri , Nanan Nur'aeny , Irna Sufiawati

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引用次数: 0

摘要

背景超过四分之一的 17 岁及以上人口和十分之一的 2-17 岁儿童的口腔黏膜会发生变化，并影响与口腔健康相关的生活质量。口腔黏膜疾病影响口腔，而且种类繁多。据报道，口腔黏膜病与多种因素有关，如维生素 B12 缺乏。本系统综述旨在研究口腔黏膜病患者的维生素 B12 血清水平。通过 PubMed、Science Direct 和 Ebscohost-CINAHL 对 2018 年至 2023 年发表的文章进行了特定关键词检索。文章搜索仅限于人类研究、横断面和病例对照设计、英文撰写的论文，并提供全文。偏倚风险评估采用了美国国家心肺血液研究所（NHLBI）的工具。结果对符合纳入标准的12篇文章进行了分析。研究的口腔黏膜疾病类型包括萎缩性舌炎（3 篇）、OLP（2 篇）、RAS（2 篇）、OSF（2 篇）、BMS（1 篇）、地理舌（1 篇）和口腔癌前病变（1 篇）。在 9 篇文章中，OMD 患者的维生素 B12 水平明显低于健康对照组，而在 3 篇文章中，患者的维生素 B12 水平与健康对照组相近。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Vitamin B12 levels in patients with oral mucosal diseases (OMD): A systematic review

Background

Changes in the oral mucosa occur in more than one-fourth of the population aged 17 and older and in one-tenth of children aged 2–17 years old, and consequence on the oral health-related quality of life. Oral mucosal diseases affect the oral cavity and vary greatly. OMDs have been reported to be associated with several factors, such as vitamin B12 deficiencies.

Objective

This systematic review aims to investigate the vitamin B12 serum levels in patients with OMD.

Method

This systematic review was conducted using the Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) guidelines. Article searches with specific keywords were conducted through PubMed, Science Direct, and Ebscohost-CINAHL, published from 2018 to 2023. The search for articles was limited to human studies, cross-sectional and case-control designs, papers written in English, and the full-text availability. The risk assessment of bias uses tools from the National Heart, Lung, and Blood Institute (NHLBI).

Results

Twelve articles that meet the inclusion criteria were analyzed. The types of oral mucosal disease studied include atrophic glossitis (3 articles), OLP (2 articles), RAS (2 articles), OSF (2 articles), BMS (1 article), geographic tongue (1 article), and oral precancer (1 article). Vitamin B12 levels in OMD patients were significantly lower than healthy controls in 9 articles, while the levels were similar in 3 articles.