埃及基因组：迈向非洲基因组新时代。

IF 11.4 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Journal of Advanced Research Pub Date : 2025-05-01 DOI:10.1016/j.jare.2024.06.003

Khaled Amer , Neveen A. Soliman , Sameh Soror , Yehia Z. Gad , Ahmed Moustafa , Mohamed A. Elmonem , May Amer , Ameera Ragheb , Amira Kotb , Tarek Taha , Wael Ali , Mahmoud Sakr , Khaled Abdel Ghaffar , Scientific Committee Consortium

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引用次数: 0

摘要

背景：人类基因组研究对于根据个人独特的基因构成和分子信息制定治疗和预防策略，从而实现精准医疗至关重要。在人类基因组计划（1990-2003 年）产生了第一个人类基因组全序列之后，由于其他人群的代表性不足，人们对北方人的偏见产生了担忧。目前，多个国家已建立了国家基因组项目，旨在从本国人口中获取基因组知识，进而在不久的将来为本国的医疗保健政策提供依据：本文旨在介绍最近建立的埃及基因组（Egypt Genome，EG），以描述现代和古代埃及人口的基因组学和遗传学。利用基因组医学改进精准医疗战略，同时为大规模基因组研究能力奠定坚实的基础，这是埃及基因组的根本重点：预计 EG 产生的基因组知识将丰富现有的人类基因组，并通过研究代表性不足的非洲/中东人群扩大人类基因组的多样性。EG 的深远影响超越了埃及和非洲，因为它填补了健康和疾病基因组学方面的知识空白，有助于改进以基因组学为动力的可持续医疗保健系统，从而取得更好的成果。因此，促进基因组学与临床实践的结合，率先实施基因组学驱动的医疗保健和精准医疗是 EG 的重点工作。挖掘古埃及基因组学的财富，划定当代和古埃及人口之间的基因桥梁，是 EG 实现全球人类基因组愿景的另一个令人兴奋的独特领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Egypt Genome: Towards an African new genomic era

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Egypt Genome: Towards an African new genomic era

Background

Studying the human genome is crucial to embrace precision medicine through tailoring treatment and prevention strategies to the unique genetic makeup and molecular information of individuals. After human genome project (1990–2003) generated the first full sequence of a human genome, there have been concerns towards Northern bias due to underrepresentation of other populations. Multiple countries have now established national genome projects aiming at the genomic knowledge that can be harnessed from their populations, which in turn can serve as a basis for their health care policies in the near future.

Aim of review

The intention is to introduce the recently established Egypt Genome (EG) to delineate the genomics and genetics of both the modern and Ancient Egyptian populations. Leveraging genomic medicine to improve precision medicine strategies while building a solid foundation for large-scale genomic research capacity is the fundamental focus of EG.

Key scientific concepts

EG generated genomic knowledge is predicted to enrich the existing human genome and to expand its diversity by studying the underrepresented African/Middle Eastern populations. The insightful impact of EG goes beyond Egypt and Africa as it fills the knowledge gaps in health and disease genomics towards improved and sustainable genomic-driven healthcare systems for better outcomes. Promoting the integration of genomics into clinical practice and spearheading the implementation of genomic-driven healthcare and precision medicine is therefore a key focus of EG. Mining into the wealth of Ancient Egyptian Genomics to delineate the genetic bridge between the contemporary and Ancient Egyptian populations is another excitingly unique area of EG to realize the global vision of human genome.

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来源期刊

Journal of Advanced Research Multidisciplinary-Multidisciplinary

CiteScore

21.60

自引率

0.90%

发文量

280

审稿时长

12 weeks

期刊介绍： Journal of Advanced Research (J. Adv. Res.) is an applied/natural sciences, peer-reviewed journal that focuses on interdisciplinary research. The journal aims to contribute to applied research and knowledge worldwide through the publication of original and high-quality research articles in the fields of Medicine, Pharmaceutical Sciences, Dentistry, Physical Therapy, Veterinary Medicine, and Basic and Biological Sciences. The following abstracting and indexing services cover the Journal of Advanced Research: PubMed/Medline, Essential Science Indicators, Web of Science, Scopus, PubMed Central, PubMed, Science Citation Index Expanded, Directory of Open Access Journals (DOAJ), and INSPEC.