光生物调制在间充质干细胞上的应用及其在腱细胞分化中的潜在用途。

Brendon Roets, Heidi Abrahamse, Anine Crous
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引用次数: 0

摘要

腱鞘炎是一种普遍存在且使人衰弱的肌肉骨骼疾病。其病理生理学仍存在不确定性,但人们认为它是炎症、损伤、退行性变化和失败修复机制的综合体。细胞疗法是一种新兴的再生医学模式,它利用间充质干细胞(MSC)及其后代或外泌体促进肌腱的愈合和再生。它基于间充质干细胞可分化成腱细胞(肌腱内的主要细胞类型)并促进肌腱修复的事实。光生物调节(Photobiomodulation,PBM)是一种非侵入性且具有潜在前景的治疗技术,它利用低强度光来改变细胞内过程,促进组织愈合和再生。最近的研究探讨了 PBM 通过促进间充质干细胞的活力、增殖和分化,改善间充质干细胞治疗肌腱病的潜力。同时还能促进肌腱再生。本综述重点介绍光生物调节和间充质干细胞疗法在再生医学中的应用及其在肌腱组织工程中的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Application of Photobiomodulation on Mesenchymal Stem Cells and its Potential Use for Tenocyte Differentiation.

Tendinopathy is a prevalent and debilitating musculoskeletal disorder. Uncertainty remains regarding its pathophysiology, but it is believed to be a combination of inflammation, damage, degenerative changes, and unsuccessful repair mechanisms. Cell-based therapy is an emerging regenerative medicine modality that uses mesenchymal stem cells (MSCs), their progeny or exosomes to promote tendon healing and regeneration. It is based on the fact that MSCs can be differentiated into tenocytes, the major cell type within tendons, and facilitate tendon repair. Photobiomodulation (PBM) is a non-invasive and potentially promising therapeutic technique that utilizes low-level light to alter intracellular processes and promote tissue healing and regeneration. Recent studies have examined the potential for PBM to improve MSC therapy use in tendinopathy by promoting viability, proliferation, and differentiation. As well as enhance tendon regeneration. This review focuses on Photobiomodulation and MSC therapy applications in regenerative medicine and their potential for tendon tissue engineering.

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