Association of Human Whole-blood NAD + Levels with Nabothian Cyst.

Objective: Little is known about the association between whole-blood nicotinamide adenine dinucleotide (NAD ⁺) levels and nabothian cysts. This study aimed to assess the association between NAD ⁺ levels and nabothian cysts in healthy Chinese women.

Methods: Multivariate logistic regression analysis was performed to analyze the association between NAD ⁺ levels and nabothian cysts.

Results: The mean age was 43.0 ± 11.5 years, and the mean level of NAD ⁺ was 31.3 ± 5.3 μmol/L. Nabothian cysts occurred in 184 (27.7%) participants, with single and multiple cysts in 100 (15.0%) and 84 (12.6%) participants, respectively. The total nabothian cyst prevalence gradually decreased from 37.4% to 21.6% from Q1 to Q4 of NAD ⁺ and the prevalence of single and multiple nabothian cysts also decreased across the NAD ⁺ quartiles. As compared with the highest NAD ⁺ quartile (≥ 34.4 μmol/L), the adjusted odds ratios with 95% confidence interval of the NAD ⁺ Q1 was 1.89 (1.14-3.14) for total nabothian cysts. The risk of total and single nabothian cysts linearly decreased with increasing NAD ⁺ levels, while the risk of multiple nabothian cysts decreased more rapidly at NAD ⁺ levels of 28.0 to 35.0 μmol/L.

Conclusion: Low NAD ⁺ levels were associated with an increased risk of total and multiple nabothian cysts.