使用阿莫西林/克拉维酸治疗后出现严重肝性胆汁淤积。

Q4 Medicine

Ugeskrift for laeger Pub Date : 2024-05-20 DOI:10.61409/V02240094

Michelle Meier, Peter Lykke Eriksen

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引用次数: 0

摘要

阿莫西林/克拉维酸是一种常用的抗生素。阿莫西林/克拉维酸虽然相对罕见，但其特异性药物性肝病的发病率却最高。本病例报告介绍了一位 80 岁的妇女因单纯呼吸道感染使用阿莫西林/克拉维酸钾治疗，随后因乏力、黄疸和生化胆汁淤积型（碱性磷酸酶和胆红素偏高）住院治疗。诊断过程充满挑战，最终，肝脏活检显示药物性肝损伤，在尝试了支持性对症治疗后，患者最终死亡。

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Severe hepatic cholestasis after treatment with amoxicillin/clavulanic acid.

Amoxicillin/clavulanate is a commonly used antibiotic. Though relatively rare, amoxicillin/clavulanate carries the highest incidence of idiosyncratic drug-induced liver disease. This case report presents an 80-year-old woman treated for simple respiratory tract infection with amoxicillin/clavulanate who was subsequently hospitalized with malaise and icterus and a biochemical cholestatic pattern with high alkaline phosphatase and bilirubin. Diagnostically challenging, ultimately, liver biopsy revealed drug-induced liver injury with a fatal course after attempt of supportive, symptomatic treatment.

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来源期刊

Ugeskrift for laeger Medicine-Medicine (all)

CiteScore

0.20

自引率

0.00%

发文量

345

期刊介绍： The Ulster Medical Journal is an international general medical journal with contributions on all areas of medical and surgical specialties relevant to a general medical readership. It retains a focus on material relevant to the health of the Northern Ireland population. The Honorary Editor would welcome offers of papers for publication. Prospective authors are invited to read the notice to contributors.