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ACOD1/itaconate 通路在动脉粥样硬化中的新作用。

IF 12.8 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Trends in molecular medicine Pub Date : 2024-09-01 Epub Date: 2024-06-05 DOI:10.1016/j.molmed.2024.05.015
Jingjing Xu, Suowen Xu
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引用次数: 0

摘要

作为一种内源性免疫代谢物，伊塔康酸具有出色的抗炎作用。然而，伊它康酸是否能防止动脉粥样硬化仍是未知数。最近，Song 等人和 Cyr 等人的两项研究揭示了丙酮酸脱羧酶 1/itaconate 通路在动脉粥样硬化中的新作用。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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The emerging role of ACOD1/itaconate pathway in atherosclerosis.

As an endogenous immunometabolite, itaconate has excellent anti-inflammatory effects. However, it remains unknown whether itaconate protects against atherosclerosis. Two recent studies, by Song et al. and Cyr et al., revealed the emerging role of the aconitate decarboxylase 1/itaconate pathway in atherosclerosis.

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来源期刊
Trends in molecular medicine
Trends in molecular medicine 医学-生化与分子生物学
CiteScore
24.60
自引率
0.00%
发文量
142
审稿时长
6-12 weeks
期刊介绍： Trends in Molecular Medicine (TMM) aims to offer concise and contextualized perspectives on the latest research advancing biomedical science toward better diagnosis, treatment, and prevention of human diseases. It focuses on research at the intersection of basic biology and clinical research, covering new concepts in human biology and pathology with clear implications for diagnostics and therapy. TMM reviews bridge the gap between bench and bedside, discussing research from preclinical studies to patient-enrolled trials. The major themes include disease mechanisms, tools and technologies, diagnostics, and therapeutics, with a preference for articles relevant to multiple themes. TMM serves as a platform for discussion, pushing traditional boundaries and fostering collaboration between scientists and clinicians. The journal seeks to publish provocative and authoritative articles that are also accessible to a broad audience, inspiring new directions in molecular medicine to enhance human health.
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