用于选择性吸附血清中低密度脂蛋白的双重刺激响应可再生纳米吸附剂。

IF 5.6 1区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS
Regenerative Biomaterials Pub Date : 2024-04-29 eCollection Date: 2024-01-01 DOI:10.1093/rb/rbae045
Chen Guo, Xinbang Jiang, Xiaofang Guo, Zhuang Liu, Biao Wang, Yunzheng Du, Ziying Tian, Zimeng Wang, Lailiang Ou
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引用次数: 0

摘要

利用血液灌流选择性地清除高脂血症患者血液中的超高低密度脂蛋白(LDL)被认为是防止动脉粥样硬化性心血管疾病恶化的有效方法。基于多刺激响应材料优异的结构-功能特性,我们开发了一种以功能化偶氮苯为配体的磁性光更新纳米吸附剂(Fe3O4@SiO2@Azo-COOH),它具有突出的选择性和再生特性。双刺激响应赋予了 Fe3O4@SiO2@Azo-COOH 快速分离和光生特性。该吸附剂对低密度脂蛋白具有极佳的去除效率,吸附容量为 15.06 mg/g,并且在辐照下具有高度重复吸附性能(≥5 次)。Fe3O4@SiO2@Azo-COOH 在人血清中也表现出显著的吸附特性和选择性,对低密度脂蛋白、总胆固醇和甘油三酯的吸附容量分别为 10.93、21.26 和 9.80 毫克/克,而对高密度脂蛋白(HDL)的吸附容量仅为 0.77 毫克/克,选择性吸附差(LDL/HDL)达到 93%。通过简单的再生过程实现了纳米吸附剂的完全绿色再生,经过五次再生实验,回收率保持在 99.4%。通过将动态灌流实验与微磁微流体技术相结合,LDL 含量降低了 16.6%。由于其卓越的吸附能力和再生特性,双刺激响应纳米吸附剂被认为是一种潜在的血液灌流吸附剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dual stimulus-responsive renewable nanoadsorbent for selective adsorption of low-density lipoprotein in serum.

Selective removal of ultra-high low-density lipoprotein (LDL) from the blood of hyperlipemia patients using hemoperfusion is considered an efficient method to prevent the deterioration of atherosclerotic cardiovascular disease. Based on the exceptional structure-function properties of multistimulus-responsive materials, we developed a magnetic photorenewable nanoadsorbent (Fe3O4@SiO2@Azo-COOH) with outstanding selectivity and regenerative characteristics, featuring functionalized azobenzene as the ligand. The dual-stimulus response endowed Fe3O4@SiO2@Azo-COOH with rapid separation and photoregenerative properties. The adsorbent demonstrated excellent removal efficiency of LDL with an adsorption capacity of 15.06 mg/g, and highly repetitive adsorption performance (≥5 cycles) under irradiation. Fe3O4@SiO2@Azo-COOH also exhibited remarkable adsorption properties and selectivity in human serum, with adsorption capacities of 10.93, 21.26 and 9.80 mg/g for LDL, total cholesterol and triglycerides and only 0.77 mg/g for high-density lipoprotein (HDL), resulting in a 93% selective adsorption difference (LDL/HDL). Complete green regeneration of the nanoadsorbent was achieved through a simple regeneration process, maintaining a recovery rate of 99.4% after five regeneration experiments. By combining dynamic perfusion experiment with micromagnetic microfluidics, the LDL content decreased by 16.6%. Due to its superior adsorption capacity and regenerative properties, the dual stimulus-responsive nanosorbent is considered a potential hemoperfusion adsorbent.

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来源期刊
Regenerative Biomaterials
Regenerative Biomaterials Materials Science-Biomaterials
CiteScore
7.90
自引率
16.40%
发文量
92
审稿时长
10 weeks
期刊介绍: Regenerative Biomaterials is an international, interdisciplinary, peer-reviewed journal publishing the latest advances in biomaterials and regenerative medicine. The journal provides a forum for the publication of original research papers, reviews, clinical case reports, and commentaries on the topics relevant to the development of advanced regenerative biomaterials concerning novel regenerative technologies and therapeutic approaches for the regeneration and repair of damaged tissues and organs. The interactions of biomaterials with cells and tissue, especially with stem cells, will be of particular focus.
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