两种阿根廷茉莉品种的 Withanolide 特征和乙酰胆碱酯酶抑制活性。

IF 2.1 4区医学 Q3 CHEMISTRY, MEDICINAL

Planta medica Pub Date : 2024-06-01 Epub Date: 2024-06-06 DOI:10.1055/a-2255-7096

Natalia P Alza, Eva M Pferschy-Wenzig, Olaf Kunert, Ana P Murray

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引用次数: 0

摘要

乙酰胆碱酯酶（AChE）抑制剂仍然是控制轻度至中度阿尔茨海默病症状的重要选择。在这项研究中，我们旨在评估两种阿根廷特有茄科植物 Jaborosa bergii 和 J. runcinata 的潜在体外 AChE 抑制活性。超高效液相色谱-DAD-HRMS代谢物分析表明，活性CH2Cl2子萃取物中存在着黄烷醇内酯。对它们进行分馏后，从 J. runcinata 中分离并鉴定出了两种已知的螺旋内酯类化合物，以及三种新的内酯类化合物，其骨架类似于 J. bergii 中的三尖杉内酯类化合物。已知化合物显示出适度的 AChE 抑制活性，而新化合物则没有活性。

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Withanolide Profile and Acetylcholinesterase Inhibitory Activity of Two Argentinean Jaborosa Species.

Acetylcholinesterase (AChE) inhibitors are still an important option for managing symptoms of mild to moderate Alzheimer's disease. In this study, we aimed to evaluate the potential in vitro AChE inhibitory activity of two Argentinian endemic Solanaceae species, Jaborosa bergii and J. runcinata. UHPLC-DAD-HRMS metabolite profiling revealed the presence of withanolides in the active CH₂Cl₂ subextracts. Their fractionation led to the isolation and identification of two known spiranoid withanolides from J. runcinata and three new withanolides with a skeleton similar to that of trechonolide-type withanolides from J. bergii. The known compounds showed moderate AChE inhibitory activity, while the new ones were inactive.

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来源期刊

Planta medica 医学-药学

CiteScore

5.10

自引率

3.70%

发文量

101

审稿时长

1.8 months

期刊介绍： Planta Medica is one of the leading international journals in the field of natural products – including marine organisms, fungi as well as micro-organisms – and medicinal plants. Planta Medica accepts original research papers, reviews, minireviews and perspectives from researchers worldwide. The journal publishes 18 issues per year. The following areas of medicinal plants and natural product research are covered: -Biological and Pharmacological Activities -Natural Product Chemistry & Analytical Studies -Pharmacokinetic Investigations -Formulation and Delivery Systems of Natural Products. The journal explicitly encourages the submission of chemically characterized extracts.