茯苓网状结构假瘤。

IF 4.4 Q1 OPHTHALMOLOGY

Ophthalmology. Retina Pub Date : 2024-11-01 DOI:10.1016/j.oret.2024.05.020

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引用次数: 0

摘要

目的：描述网状假皱纹（RPD）与蝶鞍（即 "蝶鞍-RPD"）之间特殊关联的特征，并将其与受 RPD 影响的眼睛和正常/蝶鞍进行比较：观察性、回顾性、病例对照研究：在一组中年相关性黄斑变性（AMD）人群中，我们选择了患有 RPD 和类脉络膜（即脉络膜厚度大于 250 μm）的眼睛。对照组为 RPD 眼，但无脉络膜睫状体（即脉络膜厚度小于 250 μm）：方法：评估每个 ETDRS 子区域中 RPD 的数量和阶段。此外，还使用脉络膜血管指数（CVI）和结构性光学相干断层扫描（OCT）及OCT-血管造影术（OCT-Angiography）上的脉络膜毛细血管灌注密度（PD）对脉络膜灌注情况进行了调查：主要结果测量：描述Pachy-RPD的多模态成像特征，以及与正常/脉络膜相关RPD的差异：在111只RPD眼球中，37只被纳入Pachy-RPD组，74只被纳入对照组。Pachy-RPD患者明显比RPD和正常/无视网膜患者年轻（平均年龄分别为75±16岁和82±7岁）（P=0.002）。两组患者的 RPD 总数相当（P=0.220）。然而，与对照组相比，RPD 厚膜病变眼的 1 期 RPD 数量明显较多（p 结论：与正常/无视网膜的RPD相比，RPD睫状体病变的特点是RPD阶段分布不同（即早期阶段较多，晚期阶段较少）。此外，RPD眼的脉络膜灌注指数更高。这些特征表明，脉络膜睫状体的存在可能是 RPD 演变为晚期 AMD 的一个 "保护 "因素。

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Pachy-Reticular Pseudodrusen

Purpose

To characterize the features of a peculiar association between reticular pseudodrusen (RPD) and pachychoroid (pachy-RPD) and to compare them with eyes affected by RPD and normal/leptochoroid.

Design

Observational, retrospective, case–control study.

Participants

Among a cohort of patients with intermediate age-related macular degeneration (AMD), we selected eyes with RPD and pachychoroid (i.e., choroidal thickness of >50 μm). A control group of RPD eyes but without pachychoroid (i.e., a choroidal thickness of <250 μm) was included.

Methods

Number and stages of RPD were evaluated in each ETDRS subfield. Furthermore, choroidal perfusion was investigated using the choroidal vascularity index (CVI), and choriocapillaris perfusion density (PD) on structural OCT and OCT angiography.

Main Outcome Measures

Description of the multimodal imaging features of pachy-RPD and differences with RPD associated with normal/leptochoroid.

Results

Among 111 RPD eyes, 37 were included in the pachy-RPD group and 74 in the control group. Patients with pachy-RPD were significantly younger than patients with RPD and normal/leptochoroid (mean age, 75 ± 16 and 82 ± 7 years, respectively; P = 0.002). Total RPD number was comparable between the 2 groups (P = 0.220). However, pachy-RPD eyes showed a significantly higher number of stage 1 RPD in comparison to the controls (P < 0.001), and a lower number of stage 3 (P < 0.001) and stage 4 RPD (P = 0.052). The CVI and choriocapillaris PD were greater in pachy-RPD than in the control group (P < 0.001 and P= 0.010, respectively).

Conclusions

Pachy-RPD are characterized by a different distribution of RPD stages (i.e., more early stages and fewer advanced stages) in comparison to RPD with normal/leptochoroid. Furthermore, pachy-RPD eyes showed greater perfusion indices of the choroid. These features suggest that the presence of pachychoroid could be a protective factor in the RPD evolution to the advanced AMD forms.