细胞外结构在艰难梭菌生物膜形成中的作用。

IF 2.5 3区生物学 Q3 MICROBIOLOGY

Anaerobe Pub Date : 2024-06-04 DOI:10.1016/j.anaerobe.2024.102873

Leslie A. Ronish , Baishakhi Biswas , Robert M. Bauer , Mallory E. Jacob , Kurt H. Piepenbrink

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引用次数: 0

摘要

艰难梭菌感染（CDI）对许多发达国家的医疗保健系统来说是一个昂贵且日益沉重的负担，因为它的病原微生物感染率很高。尽管有几种抗生素具有很高的应答率，但反复感染阻碍了有效治疗。复发的一个潜在机制是肠道中存在艰难梭菌生物膜，这种生物膜在抗生素疗程中持续存在。在这篇综述中，我们将介绍目前在了解艰难梭菌生物膜的形成和通过细胞外生物分子相互作用使其稳定的分子机制方面取得的进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The role of extracellular structures in Clostridioides difficile biofilm formation

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The role of extracellular structures in Clostridioides difficile biofilm formation

C. difficile infection (CDI) is a costly and increasing burden on the healthcare systems of many developed countries due to the high rates of nosocomial infections. Despite the availability of several antibiotics with high response rates, effective treatment is hampered by recurrent infections. One potential mechanism for recurrence is the existence of C. difficile biofilms in the gut which persist through the course of antibiotics. In this review, we describe current developments in understanding the molecular mechanisms by which C. difficile biofilms form and are stabilized through extracellular biomolecular interactions.

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来源期刊

Anaerobe 生物-微生物学

CiteScore

5.20

自引率

8.70%

发文量

137

审稿时长

76 days

期刊介绍： Anaerobe is essential reading for those who wish to remain at the forefront of discoveries relating to life processes of strictly anaerobes. The journal is multi-disciplinary, and provides a unique forum for those investigating anaerobic organisms that cause infections in humans and animals, as well as anaerobes that play roles in microbiomes or environmental processes. Anaerobe publishes reviews, mini reviews, original research articles, notes and case reports. Relevant topics fall into the broad categories of anaerobes in human and animal diseases, anaerobes in the microbiome, anaerobes in the environment, diagnosis of anaerobes in clinical microbiology laboratories, molecular biology, genetics, pathogenesis, toxins and antibiotic susceptibility of anaerobic bacteria.