Wen-Ling Lin , Mu-Ming Chien , Sangopas Patchara , Weu Wang , Amelia Faradina , Shih-Yi Huang , Te-Hsuan Tung , Chien-Sung Tsai , Anatoly V. Skalny , Alexey A. Tinkov , Chun-Chao Chang , Jung-Su Chang
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An interactive analysis showed that compared to those with the lowest levels (reference), individuals with the highest levels of serum PCs (pooled, M2) and the lowest essential/probably essential metals (M1) were associated with a healthier body composition and had a 76 % decreased risk of IR (odds ratio (OR)=0.24 (95 % CI: 0.06, 0.90), <em>p</em><0.05). In contrast, increased exposure to LysoPC(O-18:0/0:0) (M2) and essential metals (M2) exhibited an 8.22-times highest risk of IR (OR= 8.22 (2.07, 32.57), <em>p</em><0.05) as well as an altered body composition. 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引用次数: 0
摘要
背景最近的研究表明，磷脂酰胆碱（PCs）和溶血磷脂酰胆碱（LysoPCs）的生物活性脂质可预测不健康的代谢表型，但结果仍不一致。为了填补这一知识空白，我们研究了必需微量元素是否会影响 PC-Lyso PC 重塑途径以及胰岛素抵抗（IR）的风险。方法：我们从 99 名成年人中获得了人体测量数据和血液生化数据（葡萄糖、胰岛素和脂蛋白相关磷脂酶 A2 (Lp-PLA2)）。结果与结论除溶血多糖（O-18:0/0:0）外，体重与多糖和溶血多糖种类之间呈反 V 型。皮尔逊相关分析表明，必需/可能必需金属（硒、铜和镍：r=-0.4∼-0.7）与 PC 代谢物呈负相关，但与 LysoPC（O-18:0/0:0）呈正相关（硒、铜和镍：r=0.85-0.64）。量纲-g计算显示，必需金属元素每增加一个量纲，血清脂蛋白磷酸酶（Lp-PLA2）就会增加2.16倍（β=2.16（95%置信区间（CI）：0.34，3.98），p=0.023），而脂蛋白磷酸酶（Lp-PLA2）是参与PC/溶血PC代谢的关键酶。一项交互分析表明，与血清中 PCs 含量最低的人（参考值）相比，血清中 PCs 含量最高的人（汇总，M2）和必需/可能必需金属含量最低的人（M1）与更健康的身体组成有关，其患 IR 的风险降低了 76%（几率比 (OR)=0.24 (95 % CI: 0.06, 0.90)，p<0.05）。与此相反，LysoPC(O-18:0/0:0) (M2) 和必需金属 (M2) 暴露增加的人患 IR 的风险是正常人的 8.22 倍（OR= 8.22 (2.07, 32.57)，p<0.05），身体成分也会发生变化。总之，过度暴露于必需/可能必需的微量元素可能会通过调节 PC/LysoPC 重塑途径，导致不健康的体重和 IR。
Essential trace element and phosphatidylcholine remodeling: Implications for body composition and insulin resistance
Background
Recent studies indicated that bioactive lipids of phosphatidylcholines (PCs) and lysophosphatidylcholines (LysoPCs) predict unhealthy metabolic phenotypes, but results remain inconsistent. To fill this knowledge gap, we investigated whether essential trace elements affect PC-Lyso PC remodeling pathways and the risk of insulin resistance (IR).
Methods
Anthropometric and blood biochemical data (glucose, insulin, and lipoprotein-associated phospholipase A2 (Lp-PLA2)) were obtained from 99 adults. Blood essential/probably essential trace elements and lipid metabolites were respectively measured by inductively coupled plasma mass spectrometry (ICP-MS), and ultra-performance liquid chromatography-mass spectrometry (UPLC-MS).
Result and Conclusion
Except for LysoPC (O-18:0/0:0), an inverse V shape was observed between body weight and PC and LysoPC species. A Pearson correlation analysis showed that essential/probably-essential metals (Se, Cu, and Ni: r=-0.4∼-0.7) were negatively correlated with PC metabolites but positively correlated with LysoPC (O-18:0/0:0) (Se, Cu, and Ni: r=0.85–0.64). Quantile-g computation showed that one quantile increase in essential metals was associated with a 2.16-fold increase in serum Lp-PLA2 (β=2.16 (95 % confidence interval (CI): 0.34, 3.98), p=0.023), which are key enzymes involved in PC/Lyso PC metabolism. An interactive analysis showed that compared to those with the lowest levels (reference), individuals with the highest levels of serum PCs (pooled, M2) and the lowest essential/probably essential metals (M1) were associated with a healthier body composition and had a 76 % decreased risk of IR (odds ratio (OR)=0.24 (95 % CI: 0.06, 0.90), p<0.05). In contrast, increased exposure to LysoPC(O-18:0/0:0) (M2) and essential metals (M2) exhibited an 8.22-times highest risk of IR (OR= 8.22 (2.07, 32.57), p<0.05) as well as an altered body composition. In conclusion, overexposure to essential/probably essential trace elements may promote an unhealthy body weight and IR through modulating PC/LysoPC remodeling pathways.
期刊介绍：
The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods.
Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.
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