Jinbin Pan , Jiaojiao Wang , Yujie Zhao , Bing Han , Gang Shu , Min Ma , Xu Wang , Xi Wei , Wenjing Hou , Shao-Kai Sun
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The Bi-DTPA, synthesized through a straightforward one-pot method, offers distinct advantages such as no need for purification, a nearly 100 % yield, large-scale production capability, and good biocompatibility. The remarkable X-ray attenuation properties of Bi-DTPA enable real-time dynamic visualization of whole GI tract under both X-ray gastroenterography and computed tomography (CT) imaging. More importantly, the leaky site and severity can be both clearly displayed during Bi-DTPA-enhanced gastroenterography in a rat model with esophageal leakage. The proposed movie-like Bi-DTPA-enhanced X-ray imaging approach presents a promising alternative to traditional GI radiography based on iodinated molecules. 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引用次数: 0
摘要
吻合口漏是胃肠道(GI)手术后最可怕的并发症之一,造影剂增强 X 射线胃肠造影术被认为是胃肠道漏的首选初步诊断方法。然而,从基础研究到临床实践,目前唯一可用于胃肠道渗漏检测的口服碘造影剂都面临着一些挑战,包括灵敏度低、碘过敏以及甲状腺疾病患者的禁忌症。在此,我们首次提出使用无碘铋螯合物(Bi-DTPA)进行电影对比增强 X 射线胃肠造影术,以实时检测消化道漏液。Bi-DTPA 通过简单的一锅法合成,具有无需纯化、收率接近 100%、可大规模生产、生物相容性好等显著优势。Bi-DTPA 具有出色的 X 射线衰减特性,可在 X 射线胃肠造影和计算机断层扫描(CT)成像下实时动态地观察整个消化道。更重要的是,在食管渗漏的大鼠模型中,Bi-DTPA 增强胃肠造影可清晰显示渗漏部位和严重程度。所提出的类似电影的 Bi-DTPA 增强 X 射线成像方法是基于碘化分子的传统胃肠道放射成像的一种有前途的替代方法。它在解决与碘相关的不良反应方面显示出巨大的潜力,并为目测胃肠道渗漏提供了另一种方法。
Real-time detection of gastrointestinal leaks via bismuth chelate-enhanced X-ray gastroenterography
Anastomotic leaks are among the most dreaded complications following gastrointestinal (GI) surgery, and contrast-enhanced X-ray gastroenterography is considered the preferred initial diagnostic method for GI leaks. However, from fundamental research to clinical practice, the only oral iodinated contrast agents currently available for GI leaks detection are facing several challenges, including low sensitivity, iodine allergy, and contraindications in patients with thyroid diseases. Herein, we propose a cinematic contrast-enhanced X-ray gastroenterography for the real-time detection of GI leaks with an iodine-free bismuth chelate (Bi-DTPA) for the first time. The Bi-DTPA, synthesized through a straightforward one-pot method, offers distinct advantages such as no need for purification, a nearly 100 % yield, large-scale production capability, and good biocompatibility. The remarkable X-ray attenuation properties of Bi-DTPA enable real-time dynamic visualization of whole GI tract under both X-ray gastroenterography and computed tomography (CT) imaging. More importantly, the leaky site and severity can be both clearly displayed during Bi-DTPA-enhanced gastroenterography in a rat model with esophageal leakage. The proposed movie-like Bi-DTPA-enhanced X-ray imaging approach presents a promising alternative to traditional GI radiography based on iodinated molecules. It demonstrates significant potential in addressing concerns related to iodine-associated adverse effects and offers an alternative method for visually detecting gastrointestinal leaks.
期刊介绍:
Biomaterials is an international journal covering the science and clinical application of biomaterials. A biomaterial is now defined as a substance that has been engineered to take a form which, alone or as part of a complex system, is used to direct, by control of interactions with components of living systems, the course of any therapeutic or diagnostic procedure. It is the aim of the journal to provide a peer-reviewed forum for the publication of original papers and authoritative review and opinion papers dealing with the most important issues facing the use of biomaterials in clinical practice. The scope of the journal covers the wide range of physical, biological and chemical sciences that underpin the design of biomaterials and the clinical disciplines in which they are used. These sciences include polymer synthesis and characterization, drug and gene vector design, the biology of the host response, immunology and toxicology and self assembly at the nanoscale. Clinical applications include the therapies of medical technology and regenerative medicine in all clinical disciplines, and diagnostic systems that reply on innovative contrast and sensing agents. The journal is relevant to areas such as cancer diagnosis and therapy, implantable devices, drug delivery systems, gene vectors, bionanotechnology and tissue engineering.