A. Y. Al-Assafe, Rana Abdul Malik Sulaiman Al-Quaba
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New Series of Ni(II), Cu(II), Zr(IV), Ag(I), and Cd(II) Complexes of Trimethoprim and Diamine Ligands: Synthesis, Characterization, and Biological Studies
New compounds series of [M(TMP)(en)]X·nH2O and [M(TMP)(PD)]X·nH2O, where M = Ni2+, Cu2+, Zr4+, Ag+, Cd2+, TMP = trimethoprim, en = ethylenediamine, PD = o-phenylene and X= Cl− or NO3−, were prepared. The compounds were characterized using techniques including melting points, conductance, elemental analysis, FTIR, NMR, and mass spectroscopy. FTIR spectra indicated TMP acted like a bi-dentate ligand, combining via the nitrogen atoms of azomethine and pyrimidine amino groups. Diamine ligands (en or o-PD) are coordinated via two nitrogen atoms. Prepared compounds showed monomeric behavior and adopted a 6-coordinate octahedral geometry based on magnetic susceptibility and UV spectra. Conductivity measurements revealed Zr(IV) compounds were 1:2 conductive, while Ag+ and Cd2+ were 1:1 conductive; Ni2+ and Cu2+ compounds were non-conductive. Antibacterial tests on compounds and ligands against Bacillus subtilis and Staphylococcus aureus demonstrated broad-spectrum antibacterial activity. The mixed metal compounds revealed an observable tendency of antibacterial activity in the order Zr > Cd = Ag > Cu, making Zr(IV) compounds the most biologically active among them against S. aureus (Gram-positive) while the same compounds showed less antibacterial activity against B. subtilis (Gram-negative) than the free ligand.
期刊介绍:
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.