三甲氧苄啶和二胺配体的 Ni(II)、Cu(II)、Zr(IV)、Ag(I) 和 Cd(II) 新系列配合物:合成、表征和生物学研究

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
A. Y. Al-Assafe, Rana Abdul Malik Sulaiman Al-Quaba
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引用次数: 0

摘要

制备了 [M(TMP)(en)]X-nH2O 和 [M(TMP)(PD)]X-nH2O 新化合物系列,其中 M = Ni2+、Cu2+、Zr4+、Ag+、Cd2+,TMP = 三甲氧苄啶,en = 乙二胺,PD = 邻苯,X = Cl- 或 NO3-。利用熔点、电导、元素分析、傅里叶变换红外光谱、核磁共振和质谱等技术对这些化合物进行了表征。傅立叶变换红外光谱显示,TMP 的作用类似于双齿配体,通过氮甲基和嘧啶氨基的氮原子结合。二胺配体(en 或 o-PD)通过两个氮原子配位。根据磁感应强度和紫外光谱,制备的化合物显示出单体行为,并采用了 6 配位八面体几何结构。电导率测量显示,Zr(IV)化合物的电导率为 1:2,而 Ag+ 和 Cd2+ 的电导率为 1:1;Ni2+ 和 Cu2+ 化合物不导电。化合物和配体对枯草杆菌和金黄色葡萄球菌的抗菌测试表明,它们具有广谱抗菌活性。混合金属化合物显示出明显的抗菌趋势,其顺序为 Zr > Cd = Ag > Cu,其中 Zr(IV)化合物对金黄色葡萄球菌(革兰氏阳性)的生物活性最高,而相同化合物对枯草杆菌(革兰氏阴性)的抗菌活性低于游离配体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
New Series of Ni(II), Cu(II), Zr(IV), Ag(I), and Cd(II) Complexes of Trimethoprim and Diamine Ligands: Synthesis, Characterization, and Biological Studies
New compounds series of [M(TMP)(en)]X·nH2O and [M(TMP)(PD)]X·nH2O, where M = Ni2+, Cu2+, Zr4+, Ag+, Cd2+, TMP = trimethoprim, en = ethylenediamine, PD = o-phenylene and X= Cl− or NO3−, were prepared. The compounds were characterized using techniques including melting points, conductance, elemental analysis, FTIR, NMR, and mass spectroscopy. FTIR spectra indicated TMP acted like a bi-dentate ligand, combining via the nitrogen atoms of azomethine and pyrimidine amino groups. Diamine ligands (en or o-PD) are coordinated via two nitrogen atoms. Prepared compounds showed monomeric behavior and adopted a 6-coordinate octahedral geometry based on magnetic susceptibility and UV spectra. Conductivity measurements revealed Zr(IV) compounds were 1:2 conductive, while Ag+ and Cd2+ were 1:1 conductive; Ni2+ and Cu2+ compounds were non-conductive. Antibacterial tests on compounds and ligands against Bacillus subtilis and Staphylococcus aureus demonstrated broad-spectrum antibacterial activity. The mixed metal compounds revealed an observable tendency of antibacterial activity in the order Zr > Cd = Ag > Cu, making Zr(IV) compounds the most biologically active among them against S. aureus (Gram-positive) while the same compounds showed less antibacterial activity against B. subtilis (Gram-negative) than the free ligand.
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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