{"title":"用于神经电极的 TiN 纳米线和薄膜的电化学稳定性和生物相容性比较研究","authors":"Roaa Sait , Sridhar Govindarajan , Deema Hussein , Alazouf Alhowity , Saleh Baeesa , Mohammed Bangash , Adel Abuzenadah , Richard Cross","doi":"10.1016/j.electacta.2024.144527","DOIUrl":null,"url":null,"abstract":"<div><p>Neural-electrode devices with adequate charge injection capacity, long operating lifetime and excellent biocompatibility with interfaced tissues are essential to treat chronic neurological disorders. The device's efficiency hinges on the electrochemical properties of the electrode material, prompting extensive research on diverse material surfaces. Here, we investigate the electrochemical stability and biocompatibility of titanium nitride (TiN) nanowires (NWs) synthesized previously through the novel plasma enhanced chemical vapor deposition (PECVD) utilizing lower temperature as compared to conventional methods. These TiN-NWs were compared with TiN thin films, shedding light on their respective performances. TiN-NWs electrode revealed far superior electrochemical stability over 1000 cycles, achieving a capacitance retention of 93 % as compared to 68 % to that of TiN film electrode, under ambient conditions with dissolved oxygen. Additionally, impedance of TiN-NWs showed almost no change with cycling as compared to the film electrode. Moreover, our <em>in-vitro</em> cell culture spanning 20 days exhibited excellent biocompatibility for both substrates. Interestingly, cell distribution on the NWs appeared more dispersed with fewer clusters, potentially facilitating controlled electrical stimulation. These findings not only highlights the potential use of TiN-NWs for chronic stimulation of neurons, but also shows that surface morphology has a potential effect in minimising surface oxidation and improving electrochemial performance of the material.</p></div>","PeriodicalId":305,"journal":{"name":"Electrochimica Acta","volume":null,"pages":null},"PeriodicalIF":5.5000,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A comparative study of electrochemical stability and biocompatibility of TiN nanowires and thin films for neural-electrode application\",\"authors\":\"Roaa Sait , Sridhar Govindarajan , Deema Hussein , Alazouf Alhowity , Saleh Baeesa , Mohammed Bangash , Adel Abuzenadah , Richard Cross\",\"doi\":\"10.1016/j.electacta.2024.144527\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Neural-electrode devices with adequate charge injection capacity, long operating lifetime and excellent biocompatibility with interfaced tissues are essential to treat chronic neurological disorders. The device's efficiency hinges on the electrochemical properties of the electrode material, prompting extensive research on diverse material surfaces. Here, we investigate the electrochemical stability and biocompatibility of titanium nitride (TiN) nanowires (NWs) synthesized previously through the novel plasma enhanced chemical vapor deposition (PECVD) utilizing lower temperature as compared to conventional methods. These TiN-NWs were compared with TiN thin films, shedding light on their respective performances. TiN-NWs electrode revealed far superior electrochemical stability over 1000 cycles, achieving a capacitance retention of 93 % as compared to 68 % to that of TiN film electrode, under ambient conditions with dissolved oxygen. Additionally, impedance of TiN-NWs showed almost no change with cycling as compared to the film electrode. Moreover, our <em>in-vitro</em> cell culture spanning 20 days exhibited excellent biocompatibility for both substrates. Interestingly, cell distribution on the NWs appeared more dispersed with fewer clusters, potentially facilitating controlled electrical stimulation. These findings not only highlights the potential use of TiN-NWs for chronic stimulation of neurons, but also shows that surface morphology has a potential effect in minimising surface oxidation and improving electrochemial performance of the material.</p></div>\",\"PeriodicalId\":305,\"journal\":{\"name\":\"Electrochimica Acta\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.5000,\"publicationDate\":\"2024-06-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Electrochimica Acta\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0013468624007679\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ELECTROCHEMISTRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Electrochimica Acta","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0013468624007679","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ELECTROCHEMISTRY","Score":null,"Total":0}
引用次数: 0
摘要
神经电极装置具有足够的电荷注入能力、较长的工作寿命以及与界面组织良好的生物相容性,对于治疗慢性神经系统疾病至关重要。该装置的效率取决于电极材料的电化学特性,这促使人们对各种材料表面进行广泛研究。在这里,我们研究了氮化钛(TiN)纳米线(NWs)的电化学稳定性和生物相容性,这些纳米线是之前通过新型等离子体增强化学气相沉积(PECVD)技术合成的,与传统方法相比温度更低。这些 TiN-NWs 与 TiN 薄膜进行了比较,揭示了它们各自的性能。TiN-NWs 电极在 1000 次循环中显示出优越的电化学稳定性,在有溶解氧的环境条件下,电容保持率达到 93%,而 TiN 薄膜电极的电容保持率仅为 68%。此外,与薄膜电极相比,TiN-NWs 的阻抗在循环过程中几乎没有变化。此外,我们的体外细胞培养持续了 20 天,结果表明这两种基底都具有良好的生物相容性。有趣的是,NWs 上的细胞分布更分散,细胞簇更少,这可能有助于控制电刺激。这些发现不仅凸显了 TiN-NWs 用于神经元慢性刺激的潜力,而且还表明表面形态在减少表面氧化和改善材料的电化学性能方面具有潜在作用。
A comparative study of electrochemical stability and biocompatibility of TiN nanowires and thin films for neural-electrode application
Neural-electrode devices with adequate charge injection capacity, long operating lifetime and excellent biocompatibility with interfaced tissues are essential to treat chronic neurological disorders. The device's efficiency hinges on the electrochemical properties of the electrode material, prompting extensive research on diverse material surfaces. Here, we investigate the electrochemical stability and biocompatibility of titanium nitride (TiN) nanowires (NWs) synthesized previously through the novel plasma enhanced chemical vapor deposition (PECVD) utilizing lower temperature as compared to conventional methods. These TiN-NWs were compared with TiN thin films, shedding light on their respective performances. TiN-NWs electrode revealed far superior electrochemical stability over 1000 cycles, achieving a capacitance retention of 93 % as compared to 68 % to that of TiN film electrode, under ambient conditions with dissolved oxygen. Additionally, impedance of TiN-NWs showed almost no change with cycling as compared to the film electrode. Moreover, our in-vitro cell culture spanning 20 days exhibited excellent biocompatibility for both substrates. Interestingly, cell distribution on the NWs appeared more dispersed with fewer clusters, potentially facilitating controlled electrical stimulation. These findings not only highlights the potential use of TiN-NWs for chronic stimulation of neurons, but also shows that surface morphology has a potential effect in minimising surface oxidation and improving electrochemial performance of the material.
期刊介绍:
Electrochimica Acta is an international journal. It is intended for the publication of both original work and reviews in the field of electrochemistry. Electrochemistry should be interpreted to mean any of the research fields covered by the Divisions of the International Society of Electrochemistry listed below, as well as emerging scientific domains covered by ISE New Topics Committee.