V. Sh. Saberov, N. I. Korotkikh, A. S. Avksentiev, V. I. Yenya, G. F. Rayenko
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Catalytic Properties of Sterically Shielded Carbene Complexes of Palladium in C–C and C–N Coupling Reactions of Haloarenes
New carbene complex catalysts based on palladium chloride, including PEPPSI-complexes (PEPPSI = Pyridine-Enhanced Precatalyst Preparation Stabilization and Initiation), have been synthesized. These catalysts show high efficiency in Buchwald–Hartwig C–N cross-coupling between aryl chlorides/bromides and amines, including sterically shielded reagents, and high efficiency in the Suzuki–Miyaura C–C cross-coupling reaction, where their use results in the formation of several tetra-ortho-substituted biaryls at very low amounts of catalyst under mild conditions. Modification of the catalyst structure to the PEPPSI complex leads to an unexpected decrease in activity in the Buchwald–Hartwig amination, in contrast to the Suzuki–Miyaura reaction, in which the PEPPSI complex showed greater activity in some cases.
期刊介绍:
Theoretical and Experimental Chemistry is a journal for the rapid publication of research communications and reviews on modern problems of physical chemistry such as:
a) physicochemical bases, principles, and methods for creation of novel processes, compounds, and materials;
b) physicochemical principles of chemical process control, influence of external physical forces on chemical reactions;
c) physical nanochemistry, nanostructures and nanomaterials, functional nanomaterials, size-dependent properties of materials.