血浆鸢尾素与前瞻性队列中儿童执行功能的关系

IF 3.4 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Minyan Lan , Yu Liu , Cuihua Guo , Xuanqing He , Yujing Chen , Xuejuan Chen , Yajun Chen , Li Cai
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引用次数: 0

摘要

目的 研究儿童鸢尾素与执行功能之间的纵向相关性,以及这种相关性的性别差异。 方法 该研究在中国广州进行,涉及 330 名 6-10 岁儿童。2017年收集了基线调查和空腹血样。使用酶联免疫吸附试验(ELISA)测量血浆鸢尾素浓度。执行功能于2017年通过执行功能行为评定量表(BRIEF)进行评估,并于2年后进行随访。结果血浆鸢尾素浓度为9.04±2.18 ng/mL。男生和女生的血浆鸢尾素和BRIEF T-scores的变化值没有统计学差异。在所有样本中,血浆鸢尾素与BRIEF T-scores的变化值之间没有发现明显的关联(P > 0.05)。根据性别进行的进一步分组分析表明,女孩的血浆鸢尾素与行为调节指数(BRI,β=-0.521,95 %CI:-1.036 ∼ -0.006)、情绪控制(β=-0.649,95 %CI:-1.249 ∼ -0.049)、工作记忆 T 分数(β=-0.774,95 %CI:-1.350 ∼ -0.199)的变化值呈负相关。此外,我们首次发现血浆鸢尾素与工作记忆 T 分数变化值之间存在性别效应修正(Pinterference=0.012)。需要对其他地区或国家的人群进行进一步研究,以证实这些发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Plasma irisin associations with executive function among children in a prospective cohort

Objective

To examine the longitudinal associations between irisin and executive function among children, as well as the sex difference in this correlation.

Methods

The study involving 330 children aged 6–10 years conducted in Guangzhou, China. Baseline surveys and fasting blood samples were collected in 2017. Plasma irisin concentration was measured using Enzyme-Linked Immunosorbent Assay (ELISA). Executive function was assessed by the Behavior Rating Inventory of Executive Function (BRIEF) scale in 2017 and followed up after 2 years. Multivariable linear regression was used for association analysis.

Results

The plasma irisin concentration was 9.04±2.18 ng/mL. There was no statistical difference in plasma irisin and change values of BRIEF T-scores between boys and girls. No significant associations were found between plasma irisin and change values of BRIEF T-scores (P > 0.05) in the overall sample. Further subgroup analyses according to sex revealed that plasma irisin was negatively associated with change values of behavior regulation index (BRI, β=-0.521, 95 %CI: −1.036 ∼ −0.006), emotional control (β=-0.649, 95 %CI: −1.249 ∼ −0.049), working memory T-scores (β=-0.774, 95 %CI: −1.350 ∼ −0.199) in girls. Moreover, we firstly identified a sex effect modification in the association of plasma irisin with change values of working memory T-score (Pinterference=0.012).

Conclusions

Higher irisin concentration was associated with better executive function performance in girls. Further studies that included populations in other regions or countries are needed to confirm these findings.

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来源期刊
Psychoneuroendocrinology
Psychoneuroendocrinology 医学-精神病学
CiteScore
7.40
自引率
8.10%
发文量
268
审稿时长
66 days
期刊介绍: Psychoneuroendocrinology publishes papers dealing with the interrelated disciplines of psychology, neurobiology, endocrinology, immunology, neurology, and psychiatry, with an emphasis on multidisciplinary studies aiming at integrating these disciplines in terms of either basic research or clinical implications. One of the main goals is to understand how a variety of psychobiological factors interact in the expression of the stress response as it relates to the development and/or maintenance of neuropsychiatric illnesses.
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