为干细胞衍生β细胞的成熟提供润滑剂

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2024-06-06 DOI:10.1016/j.stem.2024.05.001

Christos Karampelias, Heiko Lickert

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引用次数: 0

摘要

获得成熟的功能性干细胞衍生胰岛素分泌β细胞是疾病建模、药物筛选和细胞替代疗法的重要一步。在本期中，Hua等人1利用单细胞多组学分析和化学筛选，确定了神经酰胺在生成成熟干细胞衍生β细胞中的关键作用。

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Greasing the machinery toward maturation of stem cell-derived β cells

Getting mature and functional stem cell-derived, insulin-producing β cells is an important step for disease modeling, drug screening, and cell replacement therapy. In this issue, Hua et al.¹ used single-cell multiomics analysis coupled with chemical screening to identify a crucial role for ceramides in generating mature stem cell-derived β cells.

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.