幽门螺旋杆菌未感染胃的胃部发育不良病变:蜂窝型腺瘤和肠型发育不良

IF 2.5 4区 医学 Q2 PATHOLOGY
Pathology International Pub Date : 2024-08-01 Epub Date: 2024-06-05 DOI:10.1111/pin.13456
Kotaro Shibagaki, Ryoji Kushima, Tsuyoshi Mishiro, Asuka Araki, Daisuke Niino, Norihisa Ishimura, Shunji Ishihara
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引用次数: 0

摘要

随着近年来日本幽门螺杆菌(Hp)耐受性胃肿瘤(HpNGN)病例的增加,相关报道也迅速增加。无论组织学类型如何,大多数 HpNGN 都表现为胃免疫表型和低恶性潜能。尤其是窝状胃腺瘤(FGA)和肠型胃发育不良(IGD)很少发展为浸润癌。FGA 是一种发生在胃底腺(oxyntic gland)粘膜的窝状上皮肿瘤,分为扁平型和覆盆子型(FGA-RA)。扁平型是一个大的、白色的扁平隆起病变,而 FGA-RA 则是一个小的淡红色息肉。在基因组学上,扁平型的特点是 APC 和 KRAS 基因突变,而 FGA-RA 的特点是 KLF4 基因中的一个常见单核苷酸变异。据报道,这种 KLF4 单核苷酸变异可诱导胃窝状上皮肿瘤发生,并激活细胞增殖和凋亡,从而导致其生长缓慢。IGD 是幽门腺粘膜发生的肠化上皮发育不良,表现为浅表凹陷性病变,周围粘膜隆起,呈胃炎样外观。从免疫组化角度看,它表现出肠道或胃肠道表型,并经常出现 p53 过表达。因此,IGD 显示出 HpNGNs 的独特特征和潜在的多步致瘤过程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gastric dysplastic lesions in Helicobacter pylori-naïve stomach: Foveolar-type adenoma and intestinal-type dysplasia.

Reports of Helicobacter pylori (Hp)-naïve gastric neoplasm (HpNGN) cases have been rapidly increasing due to the recent increase in the Hp-naïve population in Japan. Most HpNGNs exhibit the gastric immunophenotype and a low malignant potential regardless of histological type. Especially, foveolar-type gastric adenoma (FGA) and intestinal-type gastric dysplasia (IGD) rarely progress to invasive carcinoma. FGA is a foveolar epithelial neoplasm that occurs in the fundic gland (oxyntic gland) mucosa and is classified as the flat type or raspberry type (FGA-RA). The flat type is a large, whitish flatly elevated lesion while FGA-RA is a small reddish polyp. Genomically, the flat type is characterized by APC and KRAS gene mutations and FGA-RA by a common single nucleotide variant in the KLF4 gene. This KLF4 single-nucleotide variant reportedly induces gastric foveolar epithelial tumorigenesis and activates both cell proliferation and apoptosis, leading to its slow-growing nature. IGD consists of an intestinalized epithelial dysplasia that develops in the pyloric gland mucosa, characterized as a superficial depressed lesion surrounded by raised mucosa showing a gastritis-like appearance. Immunohistochemically, it exhibits an intestinal or gastrointestinal phenotype and, frequently, p53 overexpression. Thus, IGD shows unique characteristics in HpNGNs and a potential multistep tumorigenic process.

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来源期刊
Pathology International
Pathology International 医学-病理学
CiteScore
4.50
自引率
4.50%
发文量
102
审稿时长
12 months
期刊介绍: Pathology International is the official English journal of the Japanese Society of Pathology, publishing articles of excellence in human and experimental pathology. The Journal focuses on the morphological study of the disease process and/or mechanisms. For human pathology, morphological investigation receives priority but manuscripts describing the result of any ancillary methods (cellular, chemical, immunological and molecular biological) that complement the morphology are accepted. Manuscript on experimental pathology that approach pathologenesis or mechanisms of disease processes are expected to report on the data obtained from models using cellular, biochemical, molecular biological, animal, immunological or other methods in conjunction with morphology. Manuscripts that report data on laboratory medicine (clinical pathology) without significant morphological contribution are not accepted.
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