Tejas Deshmukh, Dinesh Selvakumar, Sujitha Thavapalachandran, Oliver Archer, Gemma A Figtree, Michael Feneley, Stuart M Grieve, Liza Thomas, Faraz Pathan, James J H Chong
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{"title":"猪缺血再灌注模型中左心室心肌功能的无创心脏磁共振成像测量与有创压力-容积参数的相关性","authors":"Tejas Deshmukh, Dinesh Selvakumar, Sujitha Thavapalachandran, Oliver Archer, Gemma A Figtree, Michael Feneley, Stuart M Grieve, Liza Thomas, Faraz Pathan, James J H Chong","doi":"10.1148/ryct.230252","DOIUrl":null,"url":null,"abstract":"<p><p>Purpose To assess the correlation between noninvasive cardiac MRI-derived parameters with pressure-volume (PV) loop data and evaluate changes in left ventricular function after myocardial infarction (MI). Materials and Methods Sixteen adult female swine were induced with MI, with six swine used as controls and 10 receiving platelet-derived growth factor-AB (PDGF-AB). Load-independent measures of cardiac function, including slopes of end-systolic pressure-volume relationship (ESPVR) and preload recruitable stroke work (PRSW), were obtained on day 28 after MI. Cardiac MRI was performed on day 2 and day 28 after infarct. Global longitudinal strain (GLS) and global circumferential strain (GCS) were measured. Ventriculo-arterial coupling (VAC) was derived from PV loop and cardiac MRI data. Pearson correlation analysis was performed. Results GCS (<i>r</i> = 0.60, <i>P</i> = .01), left ventricular ejection fraction (LVEF) (<i>r</i> = 0.60, <i>P</i> = .01), and cardiac MRI-derived VAC (<i>r</i> = 0.61, <i>P</i> = .01) had a significant linear relationship with ESPVR. GCS (<i>r</i> = 0.75, <i>P</i> < .001) had the strongest significant linear relationship with PRSW, followed by LVEF (<i>r</i> = 0.67, <i>P</i> = .005) and cardiac MRI-derived VAC (<i>r</i> = 0.60, <i>P</i> = .01). GLS was not significantly correlated with ESPVR or PRSW. There was a linear correlation (<i>r</i> = 0.82, <i>P</i> < .001) between VAC derived from cardiac MRI and from PV loop data. GCS (-3.5% ± 2.3 vs 0.5% ± 1.4, <i>P</i> = .007) and cardiac MRI-derived VAC (-0.6 ± 0.6 vs 0.3 ± 0.3, <i>P</i> = .001) significantly improved in the animals treated with PDGF-AB 28 days after MI compared with controls. Conclusion Cardiac MRI-derived parameters of MI correlated with invasive PV measures, with GCS showing the strongest correlation. Cardiac MRI-derived measures also demonstrated utility in assessing therapeutic benefit using PDGF-AB. <b>Keywords:</b> Cardiac MRI, Myocardial Infarction, Pressure Volume Loop, Strain Imaging, Ventriculo-arterial Coupling <i>Supplemental material is available for this article.</i> © RSNA, 2024.</p>","PeriodicalId":21168,"journal":{"name":"Radiology. Cardiothoracic imaging","volume":null,"pages":null},"PeriodicalIF":3.8000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11211950/pdf/","citationCount":"0","resultStr":"{\"title\":\"Correlation of Noninvasive Cardiac MRI Measures of Left Ventricular Myocardial Function and Invasive Pressure-Volume Parameters in a Porcine Ischemia-Reperfusion Model.\",\"authors\":\"Tejas Deshmukh, Dinesh Selvakumar, Sujitha Thavapalachandran, Oliver Archer, Gemma A Figtree, Michael Feneley, Stuart M Grieve, Liza Thomas, Faraz Pathan, James J H Chong\",\"doi\":\"10.1148/ryct.230252\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Purpose To assess the correlation between noninvasive cardiac MRI-derived parameters with pressure-volume (PV) loop data and evaluate changes in left ventricular function after myocardial infarction (MI). Materials and Methods Sixteen adult female swine were induced with MI, with six swine used as controls and 10 receiving platelet-derived growth factor-AB (PDGF-AB). Load-independent measures of cardiac function, including slopes of end-systolic pressure-volume relationship (ESPVR) and preload recruitable stroke work (PRSW), were obtained on day 28 after MI. Cardiac MRI was performed on day 2 and day 28 after infarct. Global longitudinal strain (GLS) and global circumferential strain (GCS) were measured. Ventriculo-arterial coupling (VAC) was derived from PV loop and cardiac MRI data. Pearson correlation analysis was performed. Results GCS (<i>r</i> = 0.60, <i>P</i> = .01), left ventricular ejection fraction (LVEF) (<i>r</i> = 0.60, <i>P</i> = .01), and cardiac MRI-derived VAC (<i>r</i> = 0.61, <i>P</i> = .01) had a significant linear relationship with ESPVR. GCS (<i>r</i> = 0.75, <i>P</i> < .001) had the strongest significant linear relationship with PRSW, followed by LVEF (<i>r</i> = 0.67, <i>P</i> = .005) and cardiac MRI-derived VAC (<i>r</i> = 0.60, <i>P</i> = .01). GLS was not significantly correlated with ESPVR or PRSW. There was a linear correlation (<i>r</i> = 0.82, <i>P</i> < .001) between VAC derived from cardiac MRI and from PV loop data. GCS (-3.5% ± 2.3 vs 0.5% ± 1.4, <i>P</i> = .007) and cardiac MRI-derived VAC (-0.6 ± 0.6 vs 0.3 ± 0.3, <i>P</i> = .001) significantly improved in the animals treated with PDGF-AB 28 days after MI compared with controls. Conclusion Cardiac MRI-derived parameters of MI correlated with invasive PV measures, with GCS showing the strongest correlation. Cardiac MRI-derived measures also demonstrated utility in assessing therapeutic benefit using PDGF-AB. <b>Keywords:</b> Cardiac MRI, Myocardial Infarction, Pressure Volume Loop, Strain Imaging, Ventriculo-arterial Coupling <i>Supplemental material is available for this article.</i> © RSNA, 2024.</p>\",\"PeriodicalId\":21168,\"journal\":{\"name\":\"Radiology. Cardiothoracic imaging\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2024-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11211950/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Radiology. Cardiothoracic imaging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1148/ryct.230252\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiology. Cardiothoracic imaging","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1148/ryct.230252","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
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