Liwen Zhang , Jiayi Liu , Yuxuan Cao , Shan Liu , Weili Zhao , Ci Wang , Shangfang Banzhao , Zanchao Liu , Lipeng Liu
{"title":"2003-2004年和2011-2012年国家健康调查（NHANES）中不饱和脂肪酸循环水平与糖尿病前期风险之间的关系。","authors":"Liwen Zhang , Jiayi Liu , Yuxuan Cao , Shan Liu , Weili Zhao , Ci Wang , Shangfang Banzhao , Zanchao Liu , Lipeng Liu","doi":"10.1016/j.diabres.2024.111728","DOIUrl":null,"url":null,"abstract":"<div><h3>Aims</h3><p>This study aimed to investigate the association between serum levels of common and uncommon unsaturated fatty acids and prediabetes risk.</p></div><div><h3>Methods</h3><p>Data were collected from the National Health and Nutrition Examination Survey for 2003–2004 and 2011–2012. Weighted proportional and multivariate logistic regression analyses were performed to assess the association of serum PUFAs and MUFAs with prediabetes risk after adjusting for potential confounders.</p></div><div><h3>Results</h3><p>A total of 3575 individuals were enrolled in this study. Serum levels of PUFAs EPA (20:5 n3) and GLA (18:3 n6) were associated with increased prediabetes risk (EPA (20:5 n3): OR = 1.878, 95% CI: 1.177–2.996, <em>P<sub>trend</sub></em> = 0.002; GLA (18:3 n6): 1.702, 95% CI: 1.140–2.541, <em>P<sub>trend</sub></em> = 0.016). The MUFAs PA (16:1 n7) and EA (20:1 n9) were associated with the risk of prediabetes (OR in quintile5: PA (16:1 n7): 1.780, 95% CI: 1.056–3.001, <em>P<sub>trend</sub></em> = 0.003; EA (20:1 n9): 0.587, 95% CI: 0.347–0.994, <em>P<sub>trend</sub></em> = 0.010). Moreover, nonlinear analysis revealed that serum levels of EPA (20:5 n3) and EA (20:1 n-9) were nonlinearly associated with prediabetes risk.</p></div><div><h3>Conclusion</h3><p>Some serum n-3 PUFAs are positively associated with prediabetes, several serum n-6 PUFAs are inversely associated with prediabetes. Regulating individual serum USFA levels may help prevent prediabetes, thereby providing evidence for clinical and nutritional practices.</p></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":null,"pages":null},"PeriodicalIF":6.1000,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168822724006387/pdfft?md5=973a3a1f0578f8e7a1e5f97f10dda18c&pid=1-s2.0-S0168822724006387-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Association between circulating levels of unsaturated fatty acids and risk for prediabetes in the NHANES 2003–2004 and 2011–2012\",\"authors\":\"Liwen Zhang , Jiayi Liu , Yuxuan Cao , Shan Liu , Weili Zhao , Ci Wang , Shangfang Banzhao , Zanchao Liu , Lipeng Liu\",\"doi\":\"10.1016/j.diabres.2024.111728\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Aims</h3><p>This study aimed to investigate the association between serum levels of common and uncommon unsaturated fatty acids and prediabetes risk.</p></div><div><h3>Methods</h3><p>Data were collected from the National Health and Nutrition Examination Survey for 2003–2004 and 2011–2012. Weighted proportional and multivariate logistic regression analyses were performed to assess the association of serum PUFAs and MUFAs with prediabetes risk after adjusting for potential confounders.</p></div><div><h3>Results</h3><p>A total of 3575 individuals were enrolled in this study. Serum levels of PUFAs EPA (20:5 n3) and GLA (18:3 n6) were associated with increased prediabetes risk (EPA (20:5 n3): OR = 1.878, 95% CI: 1.177–2.996, <em>P<sub>trend</sub></em> = 0.002; GLA (18:3 n6): 1.702, 95% CI: 1.140–2.541, <em>P<sub>trend</sub></em> = 0.016). The MUFAs PA (16:1 n7) and EA (20:1 n9) were associated with the risk of prediabetes (OR in quintile5: PA (16:1 n7): 1.780, 95% CI: 1.056–3.001, <em>P<sub>trend</sub></em> = 0.003; EA (20:1 n9): 0.587, 95% CI: 0.347–0.994, <em>P<sub>trend</sub></em> = 0.010). Moreover, nonlinear analysis revealed that serum levels of EPA (20:5 n3) and EA (20:1 n-9) were nonlinearly associated with prediabetes risk.</p></div><div><h3>Conclusion</h3><p>Some serum n-3 PUFAs are positively associated with prediabetes, several serum n-6 PUFAs are inversely associated with prediabetes. Regulating individual serum USFA levels may help prevent prediabetes, thereby providing evidence for clinical and nutritional practices.</p></div>\",\"PeriodicalId\":11249,\"journal\":{\"name\":\"Diabetes research and clinical practice\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":6.1000,\"publicationDate\":\"2024-06-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S0168822724006387/pdfft?md5=973a3a1f0578f8e7a1e5f97f10dda18c&pid=1-s2.0-S0168822724006387-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Diabetes research and clinical practice\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0168822724006387\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diabetes research and clinical practice","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0168822724006387","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Association between circulating levels of unsaturated fatty acids and risk for prediabetes in the NHANES 2003–2004 and 2011–2012
Aims
This study aimed to investigate the association between serum levels of common and uncommon unsaturated fatty acids and prediabetes risk.
Methods
Data were collected from the National Health and Nutrition Examination Survey for 2003–2004 and 2011–2012. Weighted proportional and multivariate logistic regression analyses were performed to assess the association of serum PUFAs and MUFAs with prediabetes risk after adjusting for potential confounders.
Results
A total of 3575 individuals were enrolled in this study. Serum levels of PUFAs EPA (20:5 n3) and GLA (18:3 n6) were associated with increased prediabetes risk (EPA (20:5 n3): OR = 1.878, 95% CI: 1.177–2.996, Ptrend = 0.002; GLA (18:3 n6): 1.702, 95% CI: 1.140–2.541, Ptrend = 0.016). The MUFAs PA (16:1 n7) and EA (20:1 n9) were associated with the risk of prediabetes (OR in quintile5: PA (16:1 n7): 1.780, 95% CI: 1.056–3.001, Ptrend = 0.003; EA (20:1 n9): 0.587, 95% CI: 0.347–0.994, Ptrend = 0.010). Moreover, nonlinear analysis revealed that serum levels of EPA (20:5 n3) and EA (20:1 n-9) were nonlinearly associated with prediabetes risk.
Conclusion
Some serum n-3 PUFAs are positively associated with prediabetes, several serum n-6 PUFAs are inversely associated with prediabetes. Regulating individual serum USFA levels may help prevent prediabetes, thereby providing evidence for clinical and nutritional practices.
期刊介绍：
Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
