Huali Tang, Lianghua Xie, Liu Liu, Yan Shen, Ping Yang, Jiamei Wu, Xiaofang Zhao, Yi Li, Zhihong Wang, Yun Mao
{"title":"基于迪克森核磁共振成像测量的肾脏脂肪沉积与肥胖症的早期肾损伤有显著关联。","authors":"Huali Tang, Lianghua Xie, Liu Liu, Yan Shen, Ping Yang, Jiamei Wu, Xiaofang Zhao, Yi Li, Zhihong Wang, Yun Mao","doi":"10.1007/s00261-024-04391-9","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p>To investigate the renal fat deposition on Dixon-based magnetic resonance imaging (MRI) and to explore the predictive value of renal fat biomarkers of magnetic resonance (MR-RFBs) for early kidney damage in obesity.</p><h3>Methods</h3><p>This prospective study included 56 obese volunteers and 47 non-obese healthy volunteers. All volunteers underwent renal magnetic resonance examinations. The differences in MR-RFBs [including renal proton density fat fraction (PDFF), renal sinus fat volume (RSFV), and perirenal fat thickness (PRFT)] measured on Dixon-based MRI between the obese and non-obese volunteers were analyzed using a general linear model, taking sex, age, diabetes, and hypertension as covariates. The relationship between estimated glomerular filtration rate (eGFR) and demographic, laboratory, and imaging parameters in obese volunteers was examined by correlation analysis.</p><h3>Results</h3><p>Obese volunteers had higher MR-RFBs than non-obese volunteers after controlling for confounders (all <i>p</i> < 0.001). Renal PDFF (<i>r</i> = − 0.383; <i>p</i> = 0.004), RSFV (<i>r</i> = − 0.368; <i>p</i> = 0.005), and PRFT (<i>r</i> = − 0.451; <i>p</i> < 0.001) were significantly negatively correlated with eGFR in obesity. After adjusting for age, sex, body mass index, diabetes, hypertension, visceral adipose tissue, subcutaneous adipose tissue, renal PDFF, and RSFV, PRFT remained independently negatively associated with eGFR (<i>β</i> = − 0.587; <i>p</i> = 0.003).</p><h3>Conclusions</h3><p>All MR-RFBs are negatively correlated with eGFR in obesity. The MR-RFBs, especially PRFT, may have predictive value for early kidney damage in obesity.</p><h3>Graphical Abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7126,"journal":{"name":"Abdominal Radiology","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Renal fat deposition measured on dixon-based MRI is significantly associated with early kidney damage in obesity\",\"authors\":\"Huali Tang, Lianghua Xie, Liu Liu, Yan Shen, Ping Yang, Jiamei Wu, Xiaofang Zhao, Yi Li, Zhihong Wang, Yun Mao\",\"doi\":\"10.1007/s00261-024-04391-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><p>To investigate the renal fat deposition on Dixon-based magnetic resonance imaging (MRI) and to explore the predictive value of renal fat biomarkers of magnetic resonance (MR-RFBs) for early kidney damage in obesity.</p><h3>Methods</h3><p>This prospective study included 56 obese volunteers and 47 non-obese healthy volunteers. All volunteers underwent renal magnetic resonance examinations. The differences in MR-RFBs [including renal proton density fat fraction (PDFF), renal sinus fat volume (RSFV), and perirenal fat thickness (PRFT)] measured on Dixon-based MRI between the obese and non-obese volunteers were analyzed using a general linear model, taking sex, age, diabetes, and hypertension as covariates. The relationship between estimated glomerular filtration rate (eGFR) and demographic, laboratory, and imaging parameters in obese volunteers was examined by correlation analysis.</p><h3>Results</h3><p>Obese volunteers had higher MR-RFBs than non-obese volunteers after controlling for confounders (all <i>p</i> < 0.001). Renal PDFF (<i>r</i> = − 0.383; <i>p</i> = 0.004), RSFV (<i>r</i> = − 0.368; <i>p</i> = 0.005), and PRFT (<i>r</i> = − 0.451; <i>p</i> < 0.001) were significantly negatively correlated with eGFR in obesity. After adjusting for age, sex, body mass index, diabetes, hypertension, visceral adipose tissue, subcutaneous adipose tissue, renal PDFF, and RSFV, PRFT remained independently negatively associated with eGFR (<i>β</i> = − 0.587; <i>p</i> = 0.003).</p><h3>Conclusions</h3><p>All MR-RFBs are negatively correlated with eGFR in obesity. 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Renal fat deposition measured on dixon-based MRI is significantly associated with early kidney damage in obesity
Purpose
To investigate the renal fat deposition on Dixon-based magnetic resonance imaging (MRI) and to explore the predictive value of renal fat biomarkers of magnetic resonance (MR-RFBs) for early kidney damage in obesity.
Methods
This prospective study included 56 obese volunteers and 47 non-obese healthy volunteers. All volunteers underwent renal magnetic resonance examinations. The differences in MR-RFBs [including renal proton density fat fraction (PDFF), renal sinus fat volume (RSFV), and perirenal fat thickness (PRFT)] measured on Dixon-based MRI between the obese and non-obese volunteers were analyzed using a general linear model, taking sex, age, diabetes, and hypertension as covariates. The relationship between estimated glomerular filtration rate (eGFR) and demographic, laboratory, and imaging parameters in obese volunteers was examined by correlation analysis.
Results
Obese volunteers had higher MR-RFBs than non-obese volunteers after controlling for confounders (all p < 0.001). Renal PDFF (r = − 0.383; p = 0.004), RSFV (r = − 0.368; p = 0.005), and PRFT (r = − 0.451; p < 0.001) were significantly negatively correlated with eGFR in obesity. After adjusting for age, sex, body mass index, diabetes, hypertension, visceral adipose tissue, subcutaneous adipose tissue, renal PDFF, and RSFV, PRFT remained independently negatively associated with eGFR (β = − 0.587; p = 0.003).
Conclusions
All MR-RFBs are negatively correlated with eGFR in obesity. The MR-RFBs, especially PRFT, may have predictive value for early kidney damage in obesity.
期刊介绍：
Abdominal Radiology seeks to meet the professional needs of the abdominal radiologist by publishing clinically pertinent original, review and practice related articles on the gastrointestinal and genitourinary tracts and abdominal interventional and radiologic procedures. Case reports are generally not accepted unless they are the first report of a new disease or condition, or part of a special solicited section.
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Asian Society of Abdominal Radiology (ASAR)
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