通过微流控技术了解癌症转移的机械生物学。

IF 6.6 3区 医学 Q1 ENGINEERING, BIOMEDICAL
APL Bioengineering Pub Date : 2024-06-03 eCollection Date: 2024-06-01 DOI:10.1063/5.0195389
Lanfeng Liang, Xiao Song, Hao Zhao, Chwee Teck Lim
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引用次数: 0

摘要

在癌症转移过程中,癌细胞会遇到各种具有不同物理特性的微环境。这些物理特性(如张力、硬度、粘度、压缩和流体剪切力)的变化会产生影响癌细胞的生物力学线索,动态地影响多种病理生理机制。例如,致密的细胞外基质会促使癌细胞重组其细胞骨架结构,促进局限性迁移,而这种致密和受限的空间也会成为一种物理屏障,可能导致细胞核破裂。确定这些病理生理过程并了解其潜在的机械生物学机制有助于开发针对癌症转移的更有效疗法。在这篇综述中,我们概述了体外微流控装置工程的进展及其在复制肿瘤微环境以模拟体内环境方面的作用。我们强调了微流控装置适应不同微环境的潜在细胞机制。同时,我们还讨论了一些重要的机械线索,这些线索在目前的微流控设备中仍难以复制。虽然癌症机械生物学仍有许多问题有待探索,但我们相信微流控设备的发展将揭示这些物理线索如何影响癌细胞的行为。这对了解癌症转移至关重要,并有可能促进更好的药物开发和癌症治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Insights into the mechanobiology of cancer metastasis via microfluidic technologies.

During cancer metastasis, cancer cells will encounter various microenvironments with diverse physical characteristics. Changes in these physical characteristics such as tension, stiffness, viscosity, compression, and fluid shear can generate biomechanical cues that affect cancer cells, dynamically influencing numerous pathophysiological mechanisms. For example, a dense extracellular matrix drives cancer cells to reorganize their cytoskeleton structures, facilitating confined migration, while this dense and restricted space also acts as a physical barrier that potentially results in nuclear rupture. Identifying these pathophysiological processes and understanding their underlying mechanobiological mechanisms can aid in the development of more effective therapeutics targeted to cancer metastasis. In this review, we outline the advances of engineering microfluidic devices in vitro and their role in replicating tumor microenvironment to mimic in vivo settings. We highlight the potential cellular mechanisms that mediate their ability to adapt to different microenvironments. Meanwhile, we also discuss some important mechanical cues that still remain challenging to replicate in current microfluidic devices in future direction. While much remains to be explored about cancer mechanobiology, we believe the developments of microfluidic devices will reveal how these physical cues impact the behaviors of cancer cells. It will be crucial in the understanding of cancer metastasis, and potentially contributing to better drug development and cancer therapy.

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来源期刊
APL Bioengineering
APL Bioengineering ENGINEERING, BIOMEDICAL-
CiteScore
9.30
自引率
6.70%
发文量
39
审稿时长
19 weeks
期刊介绍: APL Bioengineering is devoted to research at the intersection of biology, physics, and engineering. The journal publishes high-impact manuscripts specific to the understanding and advancement of physics and engineering of biological systems. APL Bioengineering is the new home for the bioengineering and biomedical research communities. APL Bioengineering publishes original research articles, reviews, and perspectives. Topical coverage includes: -Biofabrication and Bioprinting -Biomedical Materials, Sensors, and Imaging -Engineered Living Systems -Cell and Tissue Engineering -Regenerative Medicine -Molecular, Cell, and Tissue Biomechanics -Systems Biology and Computational Biology
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