高效荧光引导化疗的植物黄酮生物素 A 靶向肿瘤策略

IF 11.1 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
Yoonbin Park, Gayoung Jo, Hoon Hyun
{"title":"高效荧光引导化疗的植物黄酮生物素 A 靶向肿瘤策略","authors":"Yoonbin Park, Gayoung Jo, Hoon Hyun","doi":"10.1002/smsc.202400111","DOIUrl":null,"url":null,"abstract":"Cancer chemotherapy using natural phytochemicals, especially including isoflavone biochanin A (BCA), has attracted considerable attention because of the potent antitumor therapeutic effect and excellent biosafety. However, the preclinical application of BCA is still generally limited by its poor water solubility and low biological availability. To overcome these important limitations, a tumor targetable hemicyanine-based near-infrared (NIR) theranostic agent is rationally designed and prepared to improve the water solubility, tumor targetability, and antitumor activity of BCA. A key point to enhance the tumor targeting efficiency of BCA is the combination of a tumor-targeted water-soluble zwitterionic NIR fluorophore (ZW800-Cl) and BCA to create the hemicyanine structure, named BCA-ZW. Owing to the long-wavelength emission (>750 nm) and large Stokes shift (72 nm) of BCA-ZW, the in vivo performance of BCA-ZW is effectively monitored. The molecularly engineered BCA-ZW not only exhibits high targeting ability to HT-29 xenograft tumors but also induces high levels of reactive oxygen species (ROS) generation in the tumor tissues. Therefore, the fluorescence-guided chemotherapy by BCA-ZW to the tumor-bearing mouse model achieves the enhanced antitumor effect of BCA. This work provides a simple but effective strategy to design NIR fluorescent phytoflavonoids as potential therapeutic agents for further biomedical applications.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"70 1","pages":""},"PeriodicalIF":11.1000,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Tumor Targeting Strategy of Phytoflavonoid Biochanin A for Efficient Fluorescence-Guided Chemotherapy\",\"authors\":\"Yoonbin Park, Gayoung Jo, Hoon Hyun\",\"doi\":\"10.1002/smsc.202400111\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Cancer chemotherapy using natural phytochemicals, especially including isoflavone biochanin A (BCA), has attracted considerable attention because of the potent antitumor therapeutic effect and excellent biosafety. However, the preclinical application of BCA is still generally limited by its poor water solubility and low biological availability. To overcome these important limitations, a tumor targetable hemicyanine-based near-infrared (NIR) theranostic agent is rationally designed and prepared to improve the water solubility, tumor targetability, and antitumor activity of BCA. A key point to enhance the tumor targeting efficiency of BCA is the combination of a tumor-targeted water-soluble zwitterionic NIR fluorophore (ZW800-Cl) and BCA to create the hemicyanine structure, named BCA-ZW. Owing to the long-wavelength emission (>750 nm) and large Stokes shift (72 nm) of BCA-ZW, the in vivo performance of BCA-ZW is effectively monitored. The molecularly engineered BCA-ZW not only exhibits high targeting ability to HT-29 xenograft tumors but also induces high levels of reactive oxygen species (ROS) generation in the tumor tissues. Therefore, the fluorescence-guided chemotherapy by BCA-ZW to the tumor-bearing mouse model achieves the enhanced antitumor effect of BCA. This work provides a simple but effective strategy to design NIR fluorescent phytoflavonoids as potential therapeutic agents for further biomedical applications.\",\"PeriodicalId\":29791,\"journal\":{\"name\":\"Small Science\",\"volume\":\"70 1\",\"pages\":\"\"},\"PeriodicalIF\":11.1000,\"publicationDate\":\"2024-06-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Small Science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/smsc.202400111\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Small Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/smsc.202400111","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

摘要

利用天然植物化学物质,特别是包括异黄酮生物黄酮 A(BCA)在内的天然植物化学物质进行癌症化疗,因其强大的抗肿瘤治疗效果和出色的生物安全性而备受关注。然而,BCA 的临床前应用仍普遍受到其水溶性差和生物可用性低的限制。为了克服这些重要的局限性,我们合理地设计和制备了一种基于半氰胺的肿瘤靶向近红外(NIR)治疗剂,以提高 BCA 的水溶性、肿瘤靶向性和抗肿瘤活性。提高 BCA 肿瘤靶向效率的关键点是将肿瘤靶向水溶性齐聚物近红外荧光团(ZW800-Cl)与 BCA 结合,形成半氰基结构,命名为 BCA-ZW。由于 BCA-ZW 具有长波长发射(750 nm)和大斯托克斯位移(72 nm),因此可以有效监测 BCA-ZW 的体内性能。分子工程BCA-ZW不仅对HT-29异种移植瘤具有高靶向能力,还能诱导肿瘤组织产生高水平的活性氧(ROS)。因此,BCA-ZW 在荧光引导下对肿瘤小鼠模型进行化疗可以增强 BCA 的抗肿瘤效果。这项工作为设计近红外荧光植物黄酮类化合物作为潜在的治疗药物提供了一种简单而有效的策略,可进一步应用于生物医学领域。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A Tumor Targeting Strategy of Phytoflavonoid Biochanin A for Efficient Fluorescence-Guided Chemotherapy

A Tumor Targeting Strategy of Phytoflavonoid Biochanin A for Efficient Fluorescence-Guided Chemotherapy
Cancer chemotherapy using natural phytochemicals, especially including isoflavone biochanin A (BCA), has attracted considerable attention because of the potent antitumor therapeutic effect and excellent biosafety. However, the preclinical application of BCA is still generally limited by its poor water solubility and low biological availability. To overcome these important limitations, a tumor targetable hemicyanine-based near-infrared (NIR) theranostic agent is rationally designed and prepared to improve the water solubility, tumor targetability, and antitumor activity of BCA. A key point to enhance the tumor targeting efficiency of BCA is the combination of a tumor-targeted water-soluble zwitterionic NIR fluorophore (ZW800-Cl) and BCA to create the hemicyanine structure, named BCA-ZW. Owing to the long-wavelength emission (>750 nm) and large Stokes shift (72 nm) of BCA-ZW, the in vivo performance of BCA-ZW is effectively monitored. The molecularly engineered BCA-ZW not only exhibits high targeting ability to HT-29 xenograft tumors but also induces high levels of reactive oxygen species (ROS) generation in the tumor tissues. Therefore, the fluorescence-guided chemotherapy by BCA-ZW to the tumor-bearing mouse model achieves the enhanced antitumor effect of BCA. This work provides a simple but effective strategy to design NIR fluorescent phytoflavonoids as potential therapeutic agents for further biomedical applications.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
14.00
自引率
2.40%
发文量
0
期刊介绍: Small Science is a premium multidisciplinary open access journal dedicated to publishing impactful research from all areas of nanoscience and nanotechnology. It features interdisciplinary original research and focused review articles on relevant topics. The journal covers design, characterization, mechanism, technology, and application of micro-/nanoscale structures and systems in various fields including physics, chemistry, materials science, engineering, environmental science, life science, biology, and medicine. It welcomes innovative interdisciplinary research and its readership includes professionals from academia and industry in fields such as chemistry, physics, materials science, biology, engineering, and environmental and analytical science. Small Science is indexed and abstracted in CAS, DOAJ, Clarivate Analytics, ProQuest Central, Publicly Available Content Database, Science Database, SCOPUS, and Web of Science.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信