A covalent organic framework-based nanoplatform with enhanced photothermal and photodynamic performance for targeted tumor therapy†

In conventional tumor therapy, most nanomaterials accumulate non-specifically in target areas through enhanced permeability and retention effects, leading to poor therapeutic outcomes. In this paper, a multifunctional composite nanotherapeutic platform COF/ICG@PDA-Apt-A was prepared for targeted and combined photothermal–photodynamic therapy of tumors. The successful introduction of indocyanine green and polydopamine greatly enhanced the photothermal (photothermal conversion efficiency of up to 43.3%) and photodynamic performance of the nanotherapeutic platform. Under the active targeting action of the aptamer, the nanotherapeutic platform showed satisfactory anti-tumor ability through combination therapy. This work may contribute to the development of new active targeted delivery platforms, improving delivery efficiency and therapeutic effectiveness.