N- 烷氧基和 N- 芳氧羰基吡咯烷的电化学直接α-酰胺化和α-吡嗪化反应

IF 9.2 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Green Chemistry Pub Date : 2024-06-17 DOI:10.1039/d4gc01689k

Zhuang Wang , Yuxiu Liu , Hongjian Song , Qingmin Wang

{"title":"N- 烷氧基和 N- 芳氧羰基吡咯烷的电化学直接α-酰胺化和α-吡嗪化反应","authors":"Zhuang Wang , Yuxiu Liu , Hongjian Song , Qingmin Wang","doi":"10.1039/d4gc01689k","DOIUrl":null,"url":null,"abstract":"<div><p>We have developed a straightforward electrochemical protocol for direct α-amidation and α-pyrazolation of <em>N</em>-alkoxy- and <em>N</em>-aryloxycarbonyl pyrrolidines with amides or pyrazoles. Unlike previously reported methods, this protocol does not require pre-prepared amidation reagents, thereby shortening the synthesis route and boosting atom economy. Various functional groups are tolerated, and the reaction proceeds at room temperature in only 2.5 h without assistance from chemical oxidants or catalysts.</p></div>","PeriodicalId":78,"journal":{"name":"Green Chemistry","volume":"26 12","pages":"Pages 7419-7423"},"PeriodicalIF":9.2000,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Electrochemical direct α-amidation and α-pyrazolation of N-alkoxy- and N-aryloxycarbonyl pyrrolidines†\",\"authors\":\"Zhuang Wang , Yuxiu Liu , Hongjian Song , Qingmin Wang\",\"doi\":\"10.1039/d4gc01689k\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>We have developed a straightforward electrochemical protocol for direct α-amidation and α-pyrazolation of <em>N</em>-alkoxy- and <em>N</em>-aryloxycarbonyl pyrrolidines with amides or pyrazoles. Unlike previously reported methods, this protocol does not require pre-prepared amidation reagents, thereby shortening the synthesis route and boosting atom economy. Various functional groups are tolerated, and the reaction proceeds at room temperature in only 2.5 h without assistance from chemical oxidants or catalysts.</p></div>\",\"PeriodicalId\":78,\"journal\":{\"name\":\"Green Chemistry\",\"volume\":\"26 12\",\"pages\":\"Pages 7419-7423\"},\"PeriodicalIF\":9.2000,\"publicationDate\":\"2024-06-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Green Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S1463926224005582\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Green Chemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1463926224005582","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

我们开发了一种直接的电化学方法，用于将 N-烷氧基和 N-芳氧羰基吡咯烷与酰胺或吡唑直接进行α-酰胺化和α-吡唑化。与之前报道的方法不同，本方案无需预先制备酰胺化试剂，从而缩短了合成路线，提高了原子经济性。该方法可容忍各种官能团，而且反应在室温下进行仅需 2.5 小时，无需化学氧化剂或催化剂的辅助。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Electrochemical direct α-amidation and α-pyrazolation of N-alkoxy- and N-aryloxycarbonyl pyrrolidines†

查看原文本刊更多论文

Electrochemical direct α-amidation and α-pyrazolation of N-alkoxy- and N-aryloxycarbonyl pyrrolidines†

We have developed a straightforward electrochemical protocol for direct α-amidation and α-pyrazolation of N-alkoxy- and N-aryloxycarbonyl pyrrolidines with amides or pyrazoles. Unlike previously reported methods, this protocol does not require pre-prepared amidation reagents, thereby shortening the synthesis route and boosting atom economy. Various functional groups are tolerated, and the reaction proceeds at room temperature in only 2.5 h without assistance from chemical oxidants or catalysts.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Green Chemistry 化学-化学综合

CiteScore

16.10

自引率

7.10%

发文量

677

审稿时长

1.4 months

期刊介绍： Green Chemistry is a journal that provides a unique forum for the publication of innovative research on the development of alternative green and sustainable technologies. The scope of Green Chemistry is based on the definition proposed by Anastas and Warner (Green Chemistry: Theory and Practice, P T Anastas and J C Warner, Oxford University Press, Oxford, 1998), which defines green chemistry as the utilisation of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture and application of chemical products. Green Chemistry aims to reduce the environmental impact of the chemical enterprise by developing a technology base that is inherently non-toxic to living things and the environment. The journal welcomes submissions on all aspects of research relating to this endeavor and publishes original and significant cutting-edge research that is likely to be of wide general appeal. For a work to be published, it must present a significant advance in green chemistry, including a comparison with existing methods and a demonstration of advantages over those methods.