活鸡卵胚胎作为深层表面增强拉曼光谱的替代体内肿瘤模型

IF 3.3 3区化学 Q2 CHEMISTRY, ANALYTICAL

Analyst Pub Date : 2024-06-04 DOI:10.1039/D4AN00617H

Samantha M. McCabe, Hannah Gardiner, Calum Mullen, Gregory Q. Wallace, Neil C. Shand, Alexander B. Mullen, Linda Horan, Duncan Graham, Karen Faulds and Marie Boyd

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引用次数: 0

摘要

与传统的啮齿类动物模型相比，活体鸡卵胚胎为体内研究提供了评估和持续监测肿瘤生长的新机会。在这里，我们报告了首次使用表面增强拉曼散射（SERS）绘图和表面增强空间偏移拉曼散射（SESORS）在携带人类胶质母细胞瘤肿瘤的活鸡蛋胚中检测和定位靶向金纳米粒子的情况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Live chicken egg embryos as an alternative in vivo tumour model for deep surface enhanced Raman spectroscopy†

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Live chicken egg embryos as an alternative in vivo tumour model for deep surface enhanced Raman spectroscopy†

Live chicken egg embryos offer new opportunities for evaluation and continuous monitoring of tumour growth for in vivo studies compared to traditional rodent models. Here, we report the first use of surface enhanced Raman scattering (SERS) mapping and surface enhanced spatially offset Raman scattering (SESORS) for the detection and localisation of targeted gold nanoparticles in live chicken egg embryos bearing a glioblastoma tumour.

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