Norman Paege, Sabrina Feustel, Philip Marx-Stoelting
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引用次数: 0
摘要
微生物次生代谢物(SM)的风险评估(RA)是欧盟植物保护产品(PPP)中使用的微生物活性物质(AS)审批程序的一部分。由于某种微生物菌株可能产生的微生物次生代谢物的数量可能很多,而有关代谢物的现有信息往往很少,因此在风险评估过程中经常会发现数据缺口。通常情况下,RA 无法最终明确单个物质的毒理学相关性。本研究以 Beauvericin、2,3-deepoxy-2,3-didehydro-rhizoxin (DDR)、Leucinostatin A 和 Swainsonin 四种代谢物的数据和 RA 结论为例,详细介绍了 RA 的挑战性过程。为了克服评估报告不完整的问题,需要采用新的方法对用于购买力平价的微生物反式脂肪酸进行风险评估。鉴于下一代风险评估 (NGRA),可将文献数据、肿瘤学方法、体外方法和硅学方法结合到不良结果途径 (AOP) 中,用于高效、有针对性地识别和评估相关代谢物 (MoC)。
Toxicological evaluation of microbial secondary metabolites in the context of European active substance approval for plant protection products.
Risk assessment (RA) of microbial secondary metabolites (SM) is part of the EU approval process for microbial active substances (AS) used in plant protection products (PPP). As the number of potentially produced microbial SM may be high for a certain microbial strain and existing information on the metabolites often are low, data gaps are frequently identified during the RA. Often, RA cannot conclusively clarify the toxicological relevance of the individual substances. This work presents data and RA conclusions on four metabolites, Beauvericin, 2,3-deepoxy-2,3-didehydro-rhizoxin (DDR), Leucinostatin A and Swainsonin in detail as examples for the challenging process of RA. To overcome the problem of incomplete assessment reports, RA of microbial AS for PPP is in need of new approaches. In view of the Next Generation Risk Assessment (NGRA), the combination of literature data, omic-methods, in vitro and in silico methods combined in adverse outcome pathways (AOPs) can be used for an efficient and targeted identification and assessment of metabolites of concern (MoC).
期刊介绍:
Environmental Health publishes manuscripts on all aspects of environmental and occupational medicine and related studies in toxicology and epidemiology.
Environmental Health is aimed at scientists and practitioners in all areas of environmental science where human health and well-being are involved, either directly or indirectly. Environmental Health is a public health journal serving the public health community and scientists working on matters of public health interest and importance pertaining to the environment.