亚临床甲状腺机能减退对多囊卵巢综合征患者荷尔蒙和代谢状况以及卵巢形态的影响:一项横断面研究。

IF 2 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Gynecological Endocrinology Pub Date : 2024-12-01 Epub Date: 2024-06-04 DOI:10.1080/09513590.2024.2358219
Dongmei Shi, Juan Du, Huixian Kang, Liping Feng, Fang Liu
{"title":"亚临床甲状腺机能减退对多囊卵巢综合征患者荷尔蒙和代谢状况以及卵巢形态的影响:一项横断面研究。","authors":"Dongmei Shi, Juan Du, Huixian Kang, Liping Feng, Fang Liu","doi":"10.1080/09513590.2024.2358219","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Polycystic ovary syndrome (PCOS) and subclinical hypothyroidism (SCH) are prevalent gynecological conditions. However, the interrelationship between the two remains elusive. This study aims to elucidate the association between these conditions and determine the potential impact of SCH on the physiological and metabolic characteristics of patients with PCOS.</p><p><strong>Methods: </strong>This cross-sectional study enrolled 133 patients with PCOS from our Hospital. Participants were categorized into two groups: those with PCOS + SCH (<i>n</i> = 58) and those with PCOS (<i>n</i> = 75). Serum hormonal levels, metabolic markers, ovarian volume, and follicle count were compared between the groups.</p><p><strong>Results: </strong>There was a significant difference in BMI between the two groups, with a higher prevalence of obesity in the PCOS + SCH group (<i>p</i> = .014). Compared to the PCOS group, patients with PCOS + SCH had significantly higher levels of TSH (<i>p</i> < .001), triglycerides (<i>p</i> = .025), and HOMA-IR (<i>p</i> < .001), while LH levels were significantly lower (<i>p</i> = .048). However, multivariate linear regression analysis revealed that TSH, triglycerides, LH, and HOMA-IR were not determinants for the occurrence of SCH in patients with PCOS. Additionally, there was a notable reduction in follicle count in the left ovary for the PCOS + SCH group compared to the PCOS group (<i>p</i> = .003), and the overall follicle diameter of the PCOS + SCH group was also smaller (<i>p</i> = .010).</p><p><strong>Conclusion: </strong>SCH may exert effects on the physiological and metabolic profiles of patients with PCOS. Further investigation into the relationship between these disorders is warranted to delineate their clinical implications.</p>","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"40 1","pages":"2358219"},"PeriodicalIF":2.0000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The effect of subclinical hypothyroidism on hormonal and metabolic profiles and ovarian morphology in patients with polycystic ovary syndrome: a cross-sectional study.\",\"authors\":\"Dongmei Shi, Juan Du, Huixian Kang, Liping Feng, Fang Liu\",\"doi\":\"10.1080/09513590.2024.2358219\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>Polycystic ovary syndrome (PCOS) and subclinical hypothyroidism (SCH) are prevalent gynecological conditions. However, the interrelationship between the two remains elusive. This study aims to elucidate the association between these conditions and determine the potential impact of SCH on the physiological and metabolic characteristics of patients with PCOS.</p><p><strong>Methods: </strong>This cross-sectional study enrolled 133 patients with PCOS from our Hospital. Participants were categorized into two groups: those with PCOS + SCH (<i>n</i> = 58) and those with PCOS (<i>n</i> = 75). Serum hormonal levels, metabolic markers, ovarian volume, and follicle count were compared between the groups.</p><p><strong>Results: </strong>There was a significant difference in BMI between the two groups, with a higher prevalence of obesity in the PCOS + SCH group (<i>p</i> = .014). Compared to the PCOS group, patients with PCOS + SCH had significantly higher levels of TSH (<i>p</i> < .001), triglycerides (<i>p</i> = .025), and HOMA-IR (<i>p</i> < .001), while LH levels were significantly lower (<i>p</i> = .048). However, multivariate linear regression analysis revealed that TSH, triglycerides, LH, and HOMA-IR were not determinants for the occurrence of SCH in patients with PCOS. Additionally, there was a notable reduction in follicle count in the left ovary for the PCOS + SCH group compared to the PCOS group (<i>p</i> = .003), and the overall follicle diameter of the PCOS + SCH group was also smaller (<i>p</i> = .010).</p><p><strong>Conclusion: </strong>SCH may exert effects on the physiological and metabolic profiles of patients with PCOS. Further investigation into the relationship between these disorders is warranted to delineate their clinical implications.</p>\",\"PeriodicalId\":12865,\"journal\":{\"name\":\"Gynecological Endocrinology\",\"volume\":\"40 1\",\"pages\":\"2358219\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2024-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Gynecological Endocrinology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/09513590.2024.2358219\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/6/4 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gynecological Endocrinology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/09513590.2024.2358219","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/4 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0

摘要

目的:多囊卵巢综合征(PCOS)和亚临床甲状腺功能减退症(SCH)是普遍存在的妇科疾病。然而,二者之间的相互关系仍然难以捉摸。本研究旨在阐明这两种疾病之间的关联,并确定亚临床甲状腺功能减退症对多囊卵巢综合症患者生理和代谢特征的潜在影响:这项横断面研究共纳入了本医院的 133 名多囊卵巢综合征患者。参与者分为两组:PCOS + SCH 组(58 人)和 PCOS 组(75 人)。比较两组患者的血清激素水平、代谢指标、卵巢体积和卵泡数量:结果:两组患者的体重指数有明显差异,多囊卵巢综合征+SCH 组的肥胖率更高(p = .014)。与多囊卵巢综合征组相比,多囊卵巢综合征 + SCH 组患者的促甲状腺激素(TSH)水平(p p = .025)和 HOMA-IR 水平(p p = .048)明显更高。然而,多变量线性回归分析显示,促甲状腺激素、甘油三酯、LH 和 HOMA-IR 并不是 PCOS 患者发生 SCH 的决定因素。此外,与 PCOS 组相比,PCOS + SCH 组左侧卵巢的卵泡数量明显减少(p = .003),PCOS + SCH 组的整体卵泡直径也较小(p = .010):结论:SCH 可能会对多囊卵巢综合症患者的生理和代谢状况产生影响。结论:SCH 可能会对多囊卵巢综合症患者的生理和代谢状况产生影响,需要进一步研究这些疾病之间的关系,以确定其临床意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effect of subclinical hypothyroidism on hormonal and metabolic profiles and ovarian morphology in patients with polycystic ovary syndrome: a cross-sectional study.

Objectives: Polycystic ovary syndrome (PCOS) and subclinical hypothyroidism (SCH) are prevalent gynecological conditions. However, the interrelationship between the two remains elusive. This study aims to elucidate the association between these conditions and determine the potential impact of SCH on the physiological and metabolic characteristics of patients with PCOS.

Methods: This cross-sectional study enrolled 133 patients with PCOS from our Hospital. Participants were categorized into two groups: those with PCOS + SCH (n = 58) and those with PCOS (n = 75). Serum hormonal levels, metabolic markers, ovarian volume, and follicle count were compared between the groups.

Results: There was a significant difference in BMI between the two groups, with a higher prevalence of obesity in the PCOS + SCH group (p = .014). Compared to the PCOS group, patients with PCOS + SCH had significantly higher levels of TSH (p < .001), triglycerides (p = .025), and HOMA-IR (p < .001), while LH levels were significantly lower (p = .048). However, multivariate linear regression analysis revealed that TSH, triglycerides, LH, and HOMA-IR were not determinants for the occurrence of SCH in patients with PCOS. Additionally, there was a notable reduction in follicle count in the left ovary for the PCOS + SCH group compared to the PCOS group (p = .003), and the overall follicle diameter of the PCOS + SCH group was also smaller (p = .010).

Conclusion: SCH may exert effects on the physiological and metabolic profiles of patients with PCOS. Further investigation into the relationship between these disorders is warranted to delineate their clinical implications.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Gynecological Endocrinology
Gynecological Endocrinology 医学-妇产科学
CiteScore
4.40
自引率
5.00%
发文量
137
审稿时长
3-6 weeks
期刊介绍: Gynecological Endocrinology , the official journal of the International Society of Gynecological Endocrinology, covers all the experimental, clinical and therapeutic aspects of this ever more important discipline. It includes, amongst others, papers relating to the control and function of the different endocrine glands in females, the effects of reproductive events on the endocrine system, and the consequences of endocrine disorders on reproduction
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信