帕金森病亚型中 "脑先心病 "和 "体先心病 "的疾病进展。

IF 6.7 1区 医学 Q1 NEUROSCIENCES
Zhiheng Xu, Tianyu Hu, Chenqin Xu, Xiaoniu Liang, Shiyu Li, Yimin Sun, Fengtao Liu, Jian Wang, Yilin Tang
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引用次数: 0

摘要

根据α-突触核蛋白包涵体的初始位置,最近提出了一种新的帕金森病(PD)亚型模型,该模型将帕金森病患者分为脑先亚型和体先亚型。运动前RBD已被证明是体先亚型的预测标志物。我们发现,与不存在可能的RBD的帕金森病患者(PDpRBD-,代表脑先行亚型)相比,存在可能的运动前RBD的帕金森病患者(PDpRBD+,代表体先行亚型)在基线时的运动障碍协会统一帕金森病评分量表第三部分(MDS UPDRS-III)评分较低(p = 0.022),但纵向来看,MDS UPDRS-III评分的进展速度较快(p = 0.009)。上述发现表明,与脑先天亚型相比,体先天亚型在运动障碍方面的疾病进展更快,这进一步验证了所提出的亚型模型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Disease progression in proposed brain-first and body-first Parkinson's disease subtypes.

Disease progression in proposed brain-first and body-first Parkinson's disease subtypes.

A new Parkinson's disease (PD) subtyping model has been recently proposed based on the initial location of α-synuclein inclusions, which divides PD patients into the brain-first subtype and the body-first subtype. Premotor RBD has proven to be a predictive marker of the body-first subtype. We found compared to PD patients without possible RBD (PDpRBD-, representing the brain-first subtype), PD patients with possible premotor RBD (PDpRBD+, representing the body-first subtype) had lower Movement Disorders Society Unified Parkinson's Disease Rating Scale part III (MDS UPDRS-III) score (p = 0.022) at baseline but presented a faster progression rate (p = 0.009) in MDS UPDRS-III score longitudinally. The above finding indicates the body-first subtype exhibited a faster disease progression in motor impairments compared to the brain-first subtype and further validates the proposed subtyping model.

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来源期刊
NPJ Parkinson's Disease
NPJ Parkinson's Disease Medicine-Neurology (clinical)
CiteScore
9.80
自引率
5.70%
发文量
156
审稿时长
11 weeks
期刊介绍: npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.
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