核SMAD5在调节胰岛素分泌过程中舞动着不同的旋律

IF 27.7 1区生物学 Q1 CELL BIOLOGY

Cell metabolism Pub Date : 2024-06-04 DOI:10.1016/j.cmet.2024.05.009

John Orlowski

引用次数: 0

摘要

在本期《细胞新陈代谢》（Cell Metabolism）杂志上，Fang 等人1 报告了一种新的 pH 值敏感的细胞信号传导机制，该机制涉及转录因子 SMAD5，它能调节胰岛β细胞在饮食挑战下的胰岛素囊泡分泌。这一途径的失调可能导致代谢紊乱，如 2 型糖尿病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Nuclear SMAD5 dances to a different tune in regulating insulin secretion

In this issue of Cell Metabolism, Fang et al.¹ report a novel pH-sensitive cellular signaling mechanism involving the transcription factor SMAD5 that regulates the vesicular secretion of insulin from pancreatic β cells in response to dietary challenges. Dysregulation of this pathway may contribute to metabolic disorders such as type 2 diabetes mellitus.

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来源期刊

Cell metabolism 生物-内分泌学与代谢

CiteScore

48.60

自引率

1.40%

发文量

173

审稿时长

2.5 months

期刊介绍： Cell Metabolism is a top research journal established in 2005 that focuses on publishing original and impactful papers in the field of metabolic research.It covers a wide range of topics including diabetes, obesity, cardiovascular biology, aging and stress responses, circadian biology, and many others. Cell Metabolism aims to contribute to the advancement of metabolic research by providing a platform for the publication and dissemination of high-quality research and thought-provoking articles.