Worawan B Limpitikul , Marta Garcia-Contreras , Saumya Das
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引用次数: 0
摘要
心脏代谢疾病(CMDs)是导致全球发病率和死亡率的主要因素。最近对 CMD 发病机理的深入研究表明,代谢活跃的器官和心脏细胞之间的细胞间串扰起着至关重要的作用。在此背景下,细胞外囊泡 (EV)、含有多种货物(包括长短核糖核酸、蛋白质、脂质和代谢物)的脂膜限制颗粒以及非囊泡细胞外颗粒 (NVEP) 成为细胞间通信的关键媒介。EV货物可以反映其来源细胞的代谢状态,并影响其靶细胞的功能。了解 EV 货物的内容和功能对于揭示 CMD 的病理生理学至关重要。这篇微型综述介绍了有关 EV 在 CMDs 中介导的局部和器官间串联的最新研究,重点是那些导致心房和心室肌病的研究,这分别是心房颤动和心力衰竭的标志。最后,本综述讨论了 EV 在这些 CMD 的诊断和治疗中的潜在应用。
The emerging role of extracellular vesicle RNAs as mediators of cardiometabolic diseases: from pathophysiology to clinical applications
Cardiometabolic diseases (CMDs) are a leading contributor to worldwide morbidity and mortality. Recent insights into the pathogenesis of CMDs reveal crucial roles of intercellular crosstalk between metabolically active organs and cardiac cells. In this context, extracellular vesicles (EVs), lipid membrane-delimited particles containing diverse cargo (including small and long RNAs, proteins, lipids, and metabolites), and nonvesicular extracellular particles (NVEPs) have emerged as key mediators of cell-to-cell communications. EV cargo can reflect the metabolic state of their cells of origin and affect the function of their target cells. Understanding EV cargo content and function is essential for unraveling the pathophysiology of CMDs. This mini-review describes recent studies on EV-mediated local and interorgan crosstalk in CMDs, focusing on those that lead to atrial and ventricular myopathy, which are hallmarks of atrial fibrillation and heart failure, respectively. Lastly, this review discusses the potential applications of EVs in the diagnostics and therapeutics of these CMDs.