Lin Liu , Kaiyan Huang , Xianggui Yin , Jinyuan Wang , Yan Gao , Junpeng Shi , Fangrong Zhang , Xia Sun , Chaohui Zheng
{"title":"用于生物成像和光动力疗法的生物窗口激发上转换持续发光纳米粒子","authors":"Lin Liu , Kaiyan Huang , Xianggui Yin , Jinyuan Wang , Yan Gao , Junpeng Shi , Fangrong Zhang , Xia Sun , Chaohui Zheng","doi":"10.1016/j.jscs.2024.101893","DOIUrl":null,"url":null,"abstract":"<div><p>Near-infrared (NIR) persistent luminescence nanoparticles (PLNPs) have inherent advantages for high-sensitivity bioimaging due to the separation of excitation and emission light. However, the single-wavelength emission of NIR PLNPs for bioimaging limits their use in photodynamic therapy (PDT). Herein, a biological window excited up-conversion (UC) PLNPs, Zn<sub>3</sub>Ga<sub>2</sub>SnO<sub>8</sub>:Cr<sup>3+</sup>,Yb<sup>3+</sup>,Ho<sup>3+</sup> (ZGS), was reported for bioimaging and PDT. ZGS exhibits NIR persistent luminescence (PersL) after red LED excitation and visible UCL under 980 nm excitation. The NIR PersL is designed for <em>in vivo</em> bioimaging; the visible UCL is used to activate photosensitizer (PS) to generate reactive oxygen species (ROS) for PDT. The dual-functional ZGS with UCL and PersL provides an effective method for bioimaging and PDT, which is expected to further promote the application of PLNPs in the integration of efficient diagnosis and treatment.</p></div>","PeriodicalId":16974,"journal":{"name":"Journal of Saudi Chemical Society","volume":"28 4","pages":"Article 101893"},"PeriodicalIF":5.8000,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1319610324000887/pdfft?md5=584b2b7872add20d355c0b9e8ca7110a&pid=1-s2.0-S1319610324000887-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Biological window excited up-conversion persistent luminescence nanoparticles for bioimaging and photodynamic therapy\",\"authors\":\"Lin Liu , Kaiyan Huang , Xianggui Yin , Jinyuan Wang , Yan Gao , Junpeng Shi , Fangrong Zhang , Xia Sun , Chaohui Zheng\",\"doi\":\"10.1016/j.jscs.2024.101893\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Near-infrared (NIR) persistent luminescence nanoparticles (PLNPs) have inherent advantages for high-sensitivity bioimaging due to the separation of excitation and emission light. However, the single-wavelength emission of NIR PLNPs for bioimaging limits their use in photodynamic therapy (PDT). Herein, a biological window excited up-conversion (UC) PLNPs, Zn<sub>3</sub>Ga<sub>2</sub>SnO<sub>8</sub>:Cr<sup>3+</sup>,Yb<sup>3+</sup>,Ho<sup>3+</sup> (ZGS), was reported for bioimaging and PDT. ZGS exhibits NIR persistent luminescence (PersL) after red LED excitation and visible UCL under 980 nm excitation. The NIR PersL is designed for <em>in vivo</em> bioimaging; the visible UCL is used to activate photosensitizer (PS) to generate reactive oxygen species (ROS) for PDT. The dual-functional ZGS with UCL and PersL provides an effective method for bioimaging and PDT, which is expected to further promote the application of PLNPs in the integration of efficient diagnosis and treatment.</p></div>\",\"PeriodicalId\":16974,\"journal\":{\"name\":\"Journal of Saudi Chemical Society\",\"volume\":\"28 4\",\"pages\":\"Article 101893\"},\"PeriodicalIF\":5.8000,\"publicationDate\":\"2024-05-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1319610324000887/pdfft?md5=584b2b7872add20d355c0b9e8ca7110a&pid=1-s2.0-S1319610324000887-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Saudi Chemical Society\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1319610324000887\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Saudi Chemical Society","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1319610324000887","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Biological window excited up-conversion persistent luminescence nanoparticles for bioimaging and photodynamic therapy
Near-infrared (NIR) persistent luminescence nanoparticles (PLNPs) have inherent advantages for high-sensitivity bioimaging due to the separation of excitation and emission light. However, the single-wavelength emission of NIR PLNPs for bioimaging limits their use in photodynamic therapy (PDT). Herein, a biological window excited up-conversion (UC) PLNPs, Zn3Ga2SnO8:Cr3+,Yb3+,Ho3+ (ZGS), was reported for bioimaging and PDT. ZGS exhibits NIR persistent luminescence (PersL) after red LED excitation and visible UCL under 980 nm excitation. The NIR PersL is designed for in vivo bioimaging; the visible UCL is used to activate photosensitizer (PS) to generate reactive oxygen species (ROS) for PDT. The dual-functional ZGS with UCL and PersL provides an effective method for bioimaging and PDT, which is expected to further promote the application of PLNPs in the integration of efficient diagnosis and treatment.
期刊介绍：
Journal of Saudi Chemical Society is an English language, peer-reviewed scholarly publication in the area of chemistry. Journal of Saudi Chemical Society publishes original papers, reviews and short reports on, but not limited to:
•Inorganic chemistry
•Physical chemistry
•Organic chemistry
•Analytical chemistry
Journal of Saudi Chemical Society is the official publication of the Saudi Chemical Society and is published by King Saud University in collaboration with Elsevier and is edited by an international group of eminent researchers.
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