{"title":"沙特阿拉伯不同地区 CEA、CA 125 和 CA 15-3 血清肿瘤标志物的流行情况。","authors":"Abrar Ashi, Marwan Al-Hajeili, Sarah Almaghrabi, Jaudah Al-Maghrabi, Nora Trabulsi, Shmoukh Alghuraibi, Rawaih Alsiary, Nuha Alrayes","doi":"10.15537/smj.2024.45.6.20230878","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>To study the prevalence of tumor marker (TM) carcinoembryonic antigen (CEA), cancer antigen 125 (CA 125), and cancer antigen 15-3 (CA 15-3) levels in the Saudi population, based on gender, age, and demographic region, and whether the patients were referred by a hospital or self-referred.</p><p><strong>Methods: </strong>Retrospective analysis was carried out on 7,019 samples gathered from the Western, Northern, Central, Southern, and Eastern regions of Saudi Arabia between 2021-2022. The TMs were categorized into normal and abnormal levels, according to the reference ranges. Statistical analysis was carried out to assess the relations between variants (age groups, gender, and demographic regions) using the Chi-square test, and their correlations were assessed using Spearman's test.</p><p><strong>Results: </strong>Among all patients, CEA, CA 125, and CA 15-3 levels were found to be significantly correlated with age (<i>p</i>=0.0001). The CEA and CA 15-3 levels increased in both males and females with age. The CA 125 was shown to have an abnormally increased level in males with age.</p><p><strong>Conclusion: </strong>Increased levels of CEA, CA 125, and CA 15-3 TMs in the study population were significantly correlated with age. The CEA and CA 15-3 levels were within the normal range, while CA 125 levels were above the normal range in the older male population. These results suggest that the utilization of such TMs is age dependent and would have validity if applied with other parameters.</p>","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11147600/pdf/","citationCount":"0","resultStr":"{\"title\":\"Prevalence of CEA, CA 125, and CA 15-3 serum tumour markers in different regions of Saudi Arabia.\",\"authors\":\"Abrar Ashi, Marwan Al-Hajeili, Sarah Almaghrabi, Jaudah Al-Maghrabi, Nora Trabulsi, Shmoukh Alghuraibi, Rawaih Alsiary, Nuha Alrayes\",\"doi\":\"10.15537/smj.2024.45.6.20230878\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>To study the prevalence of tumor marker (TM) carcinoembryonic antigen (CEA), cancer antigen 125 (CA 125), and cancer antigen 15-3 (CA 15-3) levels in the Saudi population, based on gender, age, and demographic region, and whether the patients were referred by a hospital or self-referred.</p><p><strong>Methods: </strong>Retrospective analysis was carried out on 7,019 samples gathered from the Western, Northern, Central, Southern, and Eastern regions of Saudi Arabia between 2021-2022. The TMs were categorized into normal and abnormal levels, according to the reference ranges. Statistical analysis was carried out to assess the relations between variants (age groups, gender, and demographic regions) using the Chi-square test, and their correlations were assessed using Spearman's test.</p><p><strong>Results: </strong>Among all patients, CEA, CA 125, and CA 15-3 levels were found to be significantly correlated with age (<i>p</i>=0.0001). The CEA and CA 15-3 levels increased in both males and females with age. The CA 125 was shown to have an abnormally increased level in males with age.</p><p><strong>Conclusion: </strong>Increased levels of CEA, CA 125, and CA 15-3 TMs in the study population were significantly correlated with age. The CEA and CA 15-3 levels were within the normal range, while CA 125 levels were above the normal range in the older male population. These results suggest that the utilization of such TMs is age dependent and would have validity if applied with other parameters.</p>\",\"PeriodicalId\":21453,\"journal\":{\"name\":\"Saudi Medical Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2024-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11147600/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Saudi Medical Journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.15537/smj.2024.45.6.20230878\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Saudi Medical Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.15537/smj.2024.45.6.20230878","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
摘要
研究目的研究沙特人口中肿瘤标志物(TM)癌胚抗原(CEA)、癌抗原125(CA 125)和癌抗原15-3(CA 15-3)水平的患病率,以性别、年龄、人口地区以及患者是由医院转诊还是自我转诊为依据:对 2021-2022 年间从沙特阿拉伯西部、北部、中部、南部和东部地区收集的 7,019 份样本进行了回顾性分析。根据参考范围,TMs 被分为正常水平和异常水平。统计分析采用卡方检验(Chi-square test)评估变量(年龄组、性别和人口统计地区)之间的关系,并采用斯皮尔曼检验(Spearman's test)评估变量之间的相关性:在所有患者中,CEA、CA 125 和 CA 15-3 水平与年龄显著相关(P=0.0001)。男性和女性的 CEA 和 CA 15-3 水平均随年龄增长而升高。结论:结论:研究人群中 CEA、CA 125 和 CA 15-3 TMs 水平的升高与年龄显著相关。在老年男性人群中,CEA 和 CA 15-3 水平在正常范围内,而 CA 125 水平高于正常范围。这些结果表明,此类 TMs 的使用与年龄有关,如果与其他参数一起使用,将具有有效性。
Prevalence of CEA, CA 125, and CA 15-3 serum tumour markers in different regions of Saudi Arabia.
Objectives: To study the prevalence of tumor marker (TM) carcinoembryonic antigen (CEA), cancer antigen 125 (CA 125), and cancer antigen 15-3 (CA 15-3) levels in the Saudi population, based on gender, age, and demographic region, and whether the patients were referred by a hospital or self-referred.
Methods: Retrospective analysis was carried out on 7,019 samples gathered from the Western, Northern, Central, Southern, and Eastern regions of Saudi Arabia between 2021-2022. The TMs were categorized into normal and abnormal levels, according to the reference ranges. Statistical analysis was carried out to assess the relations between variants (age groups, gender, and demographic regions) using the Chi-square test, and their correlations were assessed using Spearman's test.
Results: Among all patients, CEA, CA 125, and CA 15-3 levels were found to be significantly correlated with age (p=0.0001). The CEA and CA 15-3 levels increased in both males and females with age. The CA 125 was shown to have an abnormally increased level in males with age.
Conclusion: Increased levels of CEA, CA 125, and CA 15-3 TMs in the study population were significantly correlated with age. The CEA and CA 15-3 levels were within the normal range, while CA 125 levels were above the normal range in the older male population. These results suggest that the utilization of such TMs is age dependent and would have validity if applied with other parameters.
期刊介绍:
The Saudi Medical Journal is a monthly peer-reviewed medical journal. It is an open access journal, with content released under a Creative Commons attribution-noncommercial license.
The journal publishes original research articles, review articles, Systematic Reviews, Case Reports, Brief Communication, Brief Report, Clinical Note, Clinical Image, Editorials, Book Reviews, Correspondence, and Student Corner.